MAB1358
Anti-Integrin α6B Antibody, cytoplasmic domain, clone 6B4
clone 6B4, Chemicon®, from mouse
別名:
CD49f
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この商品について
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
6B4, monoclonal
Application:
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Species reactivity:
human
Citations:
4
Technique(s):
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
immunohistochemistry: suitable
western blot: suitable
Uniprot accession no.:
製品名
Anti-Integrin α6B Antibody, cytoplasmic domain, clone 6B4, clone 6B4, Chemicon®, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
6B4, monoclonal
species reactivity
human
manufacturer/tradename
Chemicon®
technique(s)
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ITGA6(3655)
Application
Anti-Integrin α6B Antibody, cytoplasmic domain, clone 6B4 is an antibody against Integrin α6B for use in WB, IC, IH.
Western blotting: 1:100-1:500
Immunocytochemistry: 1:100-1:500 on frozen sections, 1:50-1:100 with avidin-biotin complex detection
Immunocytochemistry
Optimal working dilutions must be determined by the end user.
Immunocytochemistry: 1:100-1:500 on frozen sections, 1:50-1:100 with avidin-biotin complex detection
Immunocytochemistry
Optimal working dilutions must be determined by the end user.
Biochem/physiol Actions
MAB1358 recognizes specifically the cytoplasmic domain of integrin subunit alpha 6B. The antibody stains the basement membrane zone of ducts and acini of salivary gland, kidney tubules, epithelium of colonic crypts and weakly stains sweat glands and sebaceous glands.
Broad species reactivity is expected due to the conserved nature of the epitope.
Broad species reactivity is expected due to the conserved nature of the epitope.
General description
Integrins are a family of heterodimeric membrane glycoproteins consisting of non-covalently associated alpha and beta subunits. More than 18 alpha and 8 beta subunits with numerous splice variant isoforms have been identified in mammals. In general, integrin function as receptors for extracellular matrix proteins. Certain integrins can also bind to soluble ligands or to counter-receptors on adjacent cells, such as the intracellular adhesion molecules (ICAMs), resulting in aggregation of cells. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. For integrin subunits alpha 3 and alpha6, two cytoplasmic variants, A and B, have been identified.
Immunogen
Synthetic Peptide to the cytoplasmic domain of integrin subunit alpha6B including an appending N-terminal cysteine: CSRYDDSVPRYHAVRIRKEEREIKDEKYIDNLEKK
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Physical form
Format: Purified
Preparation Note
Store at 2-8°C, or -20°C in small aliquots for up to 12 months after date of receipt. Avoid freeze/thaw cycles.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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保管分類
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
MAB1358:
jan
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Dimpi Mukhopadhyay et al.
Cell reports, 42(11), 113347-113347 (2023-11-01)
Understanding the cell biological mechanisms that enable tumor cells to persist after therapy is necessary to improve the treatment of recurrent disease. Here, we demonstrate that transient receptor potential channel 6 (TRPC6), a channel that mediates calcium entry, contributes to
Darcie D Seachrist et al.
The Journal of biological chemistry, 295(33), 11707-11719 (2020-06-25)
The phenotypes of each breast cancer subtype are defined by their transcriptomes. However, the transcription factors that regulate differential patterns of gene expression that contribute to specific disease outcomes are not well understood. Here, using gene silencing and overexpression approaches
Reconstruction of a human hemicornea through natural scaffolds compatible with the growth of corneal epithelial stem cells and stromal keratocytes.
Barbaro, V; Ferrari, S; Fasolo, A; Ponzin, D; Di Iorio, E
Molecular Vision null
Seo-Hyun Choi et al.
Molecular cancer research : MCR, 20(8), 1305-1319 (2022-04-09)
KRAS mutation in colorectal cancer is associated with aggressive tumor behavior through increased invasiveness and higher rates of lung metastases, but the biological mechanisms behind these features are not fully understood. In this study, we show that KRAS-mutant colorectal cancer
グローバルトレードアイテム番号
| カタログ番号 | GTIN |
|---|---|
| MAB1358 | 04053252317408 |
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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