554718
REV-ERBα Antagonist, SR8278
The REV-ERBα Antagonist, SR8278 controls the biological activity of REV-ERBα.
別名:
REV-ERBα Antagonist, SR8278, SR8278SR 8278
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この商品について
実験式（ヒル表記法）:
C18H19NO3S2
CAS番号:
分子量:
361.48
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
製品名
REV-ERBα Antagonist, SR8278, The REV-ERBα Antagonist, SR8278 controls the biological activity of REV-ERBα.
InChI key
JRLOEMCOOZSCQP-UHFFFAOYSA-N
SMILES string
n1c2c(ccc1COc3cc(ccc3)C(O)CCCCC)cccc2
assay
>95% (HPLC)
form
gum
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
white to yellow-brown
solubility
DMSO: 25 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
Disclaimer
Toxicity: Regulatory Review (Z)
General description
A cell-permeable REV-ERB antagonist that inhibits REV-ERBα transcriptional repression activity (EC50 = 0.47 µM) in a REV-ERB target gene assay. It is also shown to block the ability of GSK4112 to enhance REV-ERB-&alpha-dependent repression (EC50 = 0.35 µM) in a co-transfection assay. Treatment of HepG2 cells with SR8278 at 10 µM results in a significant increase in the expression of either G6Pase and PEPCK mRNA expression, consistent with its antagonistic role against endogenous heme.
Other Notes
Kojetin, D., et al. 2010, Chem Bio in press
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Fang-Yuan Mao et al.
Cellular and molecular gastroenterology and hepatology, 12(2), 395-425 (2021-03-07)
Rev-erbα represents a powerful transcriptional repressor involved in immunity. However, the regulation, function, and clinical relevance of Rev-erbα in Helicobacter pylori infection are presently unknown. Rev-erbα was examined in gastric samples from H pylori-infected patients and mice. Gastric epithelial cells (GECs)
グローバルトレードアイテム番号
| カタログ番号 | GTIN |
|---|---|
| 554718-5MGCN | 04055977193114 |
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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