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Merck

481411

NF-κB Activation Inhibitor III

The NF-κB Activation Inhibitor III, also referenced under CAS 380623-76-7, controls the biological activity of NF-κB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

別名:

NF-κB Activation Inhibitor III, 3-Chloro-4-nitro-N-(5-nitro-2-thiazolyl)-benzamide, SM-7368

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この商品について

実験式（ヒル表記法）:
C10H5ClN4O5S
CAS番号:
380623-76-7
分子量:
328.69
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00834007

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製品名

NF-κB Activation Inhibitor III, The NF-κB Activation Inhibitor III, also referenced under CAS 380623-76-7, controls the biological activity of NF-κB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

SMILES string

[s]1c(ncc1[N+](=O)[O-])NC(=O)c2cc(c(cc2)[N+](=O)[O-])Cl

InChI

1S/C10H5ClN4O5S/c11-6-3-5(1-2-7(6)14(17)18)9(16)13-10-12-4-8(21-10)15(19)20/h1-4H,(H,12,13,16)

InChI key

XCHLNGBTHLJLFG-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

amorphous solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

light yellow

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

関連するカテゴリー

Biochem/physiol Actions

Cell permeable: yes
Effective concentration: 10 µM for complete inhibition of TNF-α-stimulated NF-κB activation and subsequent upregulation of MMP-9 in HT1080 cells
Primary Target
TNF-α-stimulated NF-κB activation and upregulation of MMP-9
Product does not compete with ATP.
Reversible: no

Disclaimer

Toxicity: Irritant (B)

General description

A cell-permeable inhibitor of TNF-α-stimulated NF-κB activation and subsequent upregulation of MMP-9 in HT1080 cells (complete inhibition at 10 µM). The inhibition of MMP-9 upregulation correlates with a concomitant inhibition of TNF-α-dependent cell invasion. Does not affect TNF-α-induced AP-1 activity. The cellular target appears to be downstream of p38 activation.
A cell-permeable thiazoloamide compound that inhibits TNF-α-stimulated NF-κB activation and subsequent upregulation of MMP-9 in HT1080 cells (complete inhibition at 10 µM). The inhibition of MMP-9 upregulation correlates with a concomitant inhibition of TNF-α-dependent cell invasion. Does not affect TNF-α-induced AP-1 activity. The cellular target appears to be downstream of p38 activation.

Other Notes

Lee, H.Y., et al. 2005. Biochem. Biophys. Res. Commun.336, 716.

Packaging

Packaged under inert gas

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

保管分類

11 - Combustible Solids

wgk

WGK 3

試験成績書（COA）

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Mohamed Hassan et al.
Oncology letters, 25(1), 41-41 (2023-01-03)
Topoisomerase inhibitors are clinically used to treat various cancer types, including colorectal cancer. These drugs also activate signaling pathways that modulate cell survival and immune cell functions. Immunotherapy is promising for certain tumors, including microsatellite instable colorectal cancer, but not
Mari E Strand et al.
Journal of molecular and cellular cardiology, 88, 133-144 (2015-10-10)
Inflammation is central to heart failure progression. Innate immune signaling increases expression of the transmembrane proteoglycan syndecan-4 in cardiac myocytes and fibroblasts, followed by shedding of its ectodomain. Circulating shed syndecan-4 is increased in heart failure patients, however the pathophysiological

グローバルトレードアイテム番号

カタログ番号GTIN
481411-5MGCN04055977183719

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