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852070 Fmoc-Thr(PO(OBzl)OH)-OH

Fmoc-Thr(PO(OBzl)OH)-OH Novabiochem®. CAS 175291-56-2, molar mass 511.47 g/mol.

Fmoc-Thr(PO(OBzl)OH)-OH MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
CAS #: 175291-56-2 Molar Mass: 511.47 g/mol Hill Formula: C₂₆H₂₆NO₈P
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Overview

Replacement Information

Key Spec Table

CAS #Hill FormulaMolar Mass
175291-56-2C₂₆H₂₆NO₈P511.47 g/mol
Description
Catalogue Number852070
Replaces04-12-1155
Brand Family Novabiochem®
Alternate Names
  • N-α-Fmoc-O-benzyl-L-phosphothreonine
Background InformationAn excellent building block for the preparation of phosphothreonine-containing peptides [1, 2]. This derivative can be introduced using standard activation methods, such as PyBOP® and TBTU. The monoprotected phosphothreonine residue once incorporated is stable to piperidine. Using this reagent, even peptides containing multiple phosphorylation sites can be prepared efficiently by standard Fmoc SPPS methods [1].

A paper describes the use of this derivative in the preparation of phospholamban [3], a 52 residue peptide containing both phosphoserine and phosphothreonine.

The product number for this product was previously 04-12-1155.

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References
Product Information
CAS number175291-56-2
Hill FormulaC₂₆H₂₆NO₈P
Molar Mass511.47 g/mol
HS Code2924 29 99
Structure formula ImageStructure formula Image
Quality LevelMQ200
Applications
ApplicationFmoc-Thr(PO(OBzl)OH)-OH Novabiochem®. CAS 175291-56-2, molar mass 511.47 g/mol.
Biological Information
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Storage class10 - 13 Other liquids and solids
WGKWGK 3 highly hazardous to water
Safety Information
Product Usage Statements
Storage and Shipping Information
StorageStore at -15°C to -25°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Color (visual)white to slight yellow to beige
Appearance of substance (visual)powder
Identity (IR)passes test
Optical rotation α 25/D (c=1 in DMF)-6.5 - -3.5 °
Purity (TLC(CMA1))≥ 98 %
Assay (HPLC, area%)≥ 98.0 % (a/a)
Solubility (1 mmole in 2 ml DMF)clearly soluble
Assay (acidimetric)≥ 90.0 %
Water (K. F.)≤ 2.0 %
Ethyl acetate (HS-GC)≤ 0.5 %
Acetate (IC)≤ 0.1 %
For TLC-Systems see our General Catalog

Documentation

Fmoc-Thr(PO(OBzl)OH)-OH SDS

Title

Safety Data Sheet (SDS) 

Citations

Title
  • [1] P. White & J. Beythien in 'Innovations & Perspectives in Solid Phase Synthesis and Combinatorial Libraries, 4th International Symposium', Mayflower Scientific Ltd., Birmingham, 1996, pp. 557.
  • [2] T. Vorherr, et al. (1995) Bioorg. Med. Chem. Lett., 5, 2661.
  • [3] H. Schmid, et al., Poster 423 presented at the 15th American Peptide Symposium, Nashville, 1997.