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176905 Anthrax Protective Antigen, Bacillus anthracis, Recombinant, B. anthracis - Calbiochem

Anthrax Protective Antigen, Bacillus anthracis, Recombinant, is the protective antigen that mediates the entry of anthrax lethal factor and edema factor into the target cell.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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176905
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Overview

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176905-100UG
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      		 Plastic ampoule 100 μg
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      Description
      OverviewRecombinant, Bacillus anthracis anthrax protective antigen expressed in a specialized strain of B. anthracis. One of the three protein components of Anthrax toxin, protective antigen (PA) is the central moiety that mediates the entry of lethal factor and edema factor into the target cell. PA binds to the cell surface via a type I membrane protein with a von Willebrand factor A domain called anthrax toxin receptor. After proteolytic activation to a 63 kDa fragment, PA self-associates to form a heptameric cation-selective, voltage-gated membrane channel.
      Catalogue Number176905
      Brand Family Calbiochem®
      References
      ReferencesMogridge, J., et al. 2002. Biochemistry 41, 1079.
      Nassi, S., et al. 2002. Biochemistry 41, 1445.
      Ahuja, N., et al. 2001. Biochem. Biophys. Res. Commun. 286, 6.
      Bradley, K.A., et al. 2001. Nature 414, 225.
      Brossier, F., and Mock, M. 2001. Toxicon 39, 1747.
      Product Information
      ATP CompetitiveN
      FormLyophilized
      FormulationLyophilized from 50 mM NaCl, 5 mM HEPES, pH 7.5.
      ReversibleN
      Quality LevelMQ100
      Applications
      ApplicationAnthrax Protective Antigen, Bacillus anthracis, Recombinant, is the protective antigen that mediates the entry of anthrax lethal factor and edema factor into the target cell.
      Biological Information
      Primary TargetType I membrane protein with a von Willebrand factor A domain called anthrax toxin receptor
      PuritySingle major band by SDS-PAGE. Several smaller minor components are apparent that may represent cleavage fragments of the PA.
      Physicochemical Information
      Cell permeableN
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions. Stock solutions are stable for up to 6 months at -20°C.
      End use certificateY
      Global Trade Item Number
      Catalogue Number GTIN
      176905-100UG 04055977223040