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287840
Sigma-AldrichDiclofenac Sodium - CAS 15307-79-6 - Calbiochem
A cell-permeable, non-selective cyclooxygenase inhibitor (IC₅₀ = 60 nM and 200 nM for ovine COX-1 and COX-2 respectively) and potent non-steroidal anti-inflammatory drug with analgesic activity.
More>>A cell-permeable, non-selective cyclooxygenase inhibitor (IC₅₀ = 60 nM and 200 nM for ovine COX-1 and COX-2 respectively) and potent non-steroidal anti-inflammatory drug with analgesic activity. Less<<
MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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Description
Overview
A cell-permeable, non-selective cyclooxygenase inhibitor (IC50 = 60 nM and 200 nM for ovine COX-1 and COX-2 respectively) and potent non-steroidal anti-inflammatory drug with analgesic activity. Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation. Also inhibits liver phenol sulfotransferase activity (IC50 = 9.5 µM).
Catalogue Number
287840
Brand Family
Calbiochem®
Synonyms
2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid, Na
References
References
Kato, M., et al. 2001. J. Pharm. Pharmacol.53, 1679. Klabunde, T., et al. 2000. Nat. Struct. Biol.7, 312. Vietri, M., et al. 2000. Eur J. Clin. Pharmacol. 56, 81. Merlos, M., et al. 1996. Inflamm. Res.45, 20. Goa, K.L., and Chrisp, P. 1992. Drugs Aging 2, 473. Kurowski, M., and Dunky, A. 1992. Int. J. Clin. Pharmacol. Ther. Toxicol. 30, 479.
60 nM and 200 nM for ovine COX-1 and COX-2 respectively; 9.5 µM against liver phenol sulfotransferase activity
Purity
≥98% by TLC
Physicochemical Information
Cell permeable
Y
Safety Information according to GHS
RTECS
AG6330000
Safety Information
R Phrase
R: 23/24/25-63
Toxic by inhalation, in contact with skin and if swallowed. Possible risk of harm to the unborn child.
S Phrase
S: 22-36
Do not breathe dust. Wear suitable protective clothing.
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention:
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage
+15°C to +30°C
Hygroscopic
Hygroscopic
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Diclofenac Sodium - CAS 15307-79-6 - Calbiochem Certificates of Analysis
Title
Lot Number
287840
References
Reference overview
Kato, M., et al. 2001. J. Pharm. Pharmacol.53, 1679. Klabunde, T., et al. 2000. Nat. Struct. Biol.7, 312. Vietri, M., et al. 2000. Eur J. Clin. Pharmacol. 56, 81. Merlos, M., et al. 1996. Inflamm. Res.45, 20. Goa, K.L., and Chrisp, P. 1992. Drugs Aging 2, 473. Kurowski, M., and Dunky, A. 1992. Int. J. Clin. Pharmacol. Ther. Toxicol. 30, 479.
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
30-April-2008 RFH
Synonyms
2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid, Na
Description
A potent non-steroidal anti-inflammatory drug that inhibits both COX-1 (IC50 = 76 nM) and COX-2 (IC50 = 26 nM) activities. Also inhibits liver phenol sulfotransferase activity (IC50 ~9.5 µM). Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation.
Form
White solid
CAS number
15307-79-6
RTECS
AG6330000
Chemical formula
C₁₄H₁₀Cl₂NO₂ · Na
Structure formula
Purity
≥98% by TLC
Solubility
H₂O (25 mg/ml)
Storage
+15°C to +30°C Hygroscopic
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Toxic & Carcinogenic / Teratogenic
Merck USA index
14, 3081
References
Kato, M., et al. 2001. J. Pharm. Pharmacol.53, 1679. Klabunde, T., et al. 2000. Nat. Struct. Biol.7, 312. Vietri, M., et al. 2000. Eur J. Clin. Pharmacol. 56, 81. Merlos, M., et al. 1996. Inflamm. Res.45, 20. Goa, K.L., and Chrisp, P. 1992. Drugs Aging 2, 473. Kurowski, M., and Dunky, A. 1992. Int. J. Clin. Pharmacol. Ther. Toxicol. 30, 479.
