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MAB1302 Mouse Anti-Human IgG Antibody, clone HP6017, Fc

Detect Human IgG using this Mouse anti-Human IgG Antibody, clone HP6017, Fc validated for use in ELISA, RIA & WB.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Secondary & Control Antibodies Research Sub-Category: Fragment Specific Secondary Antibodies Gene Symbol: FCGR2B, CDw32, CD32B, IGFR2, CD32, Fc-gamma-RIIb, FCG2, FcRII-b, FCGR2 UniProt Number: P31994
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MAB1302
500 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HELISA, RIA, WBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMAB1302
      ReplacesCBL102
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionMouse Anti-Human IgG Antibody, clone HP6017, Fc
      Product Information
      FormatPurified
      PresentationPurified immunoglobulin. Liquid in 0.02M PB, 0.25M NaCl with 0.1% sodium azide, pH=7.6.
      Quality LevelMQ100
      Applications
      ApplicationDetect Human IgG using this Mouse anti-Human IgG Antibody, clone HP6017, Fc validated for use in ELISA, RIA & WB.
      Key Applications
      • ELISA
      • Radioimmunoassay
      • Western Blotting
      Application NotesUseful as both a capture antibody and a detection antibody for human IgG Fc (Papadea et al., 1985; Hamilton, et al., 1987).

      ELISA

      Radio-immunoassay (RIA)

      Immunobloting.

      Optimal working dilutions must be determined by end user.
      Biological Information
      EpitopeFc fragment
      CloneHP6017
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityHuman IgG Fc fragment. ELISA Specificity: (Hamilton et al., 1987)

      human IgG subclass 1 100%

      human IgG subclass 2 100%

      human IgG subclass 3 100%

      human IgG subclass 4 100%

      human IgG Pan 100%

      human IgG Fc 100%

      human IgG Fab .12%



      Isoelectric Focusing: mean pI 8.0
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • FCGR2B
      • CDw32
      • CD32B
      • IGFR2
      • CD32
      • Fc-gamma-RIIb
      • FCG2
      • FcRII-b
      • FCGR2
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P31994 # Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B- cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.
      SIZE: 310 amino acids; 34044 Da
      SUBUNIT: Isoform IIB1 interacts with measles virus N protein. N protein is released in the blood following lysis of measles infected cells. This interaction presumably block inflammatory immune response. Interacts with INPP5D/SHIP1.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      TISSUE SPECIFICITY: Is the most broadly distributed Fc-gamma- receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells.
      DOMAIN: SwissProt: P31994 Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2- containing phosphatases.DISEASE:SwissProt: P31994 # A chromosomal aberration involving FCGR2B is found in a follicular lymphoma. Translocation t(1;22)(q22;q11). The translocation leads to the hyperexpression of the receptor. This may play a role in the tumor progression.
      SIMILARITY: Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8°C in undiluted aliquots for up to 12 months.
      Packaging Information
      Material Size500 µg
      Global Trade Item Number
      Catalogue Number GTIN
      MAB1302 04053252360756