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203389 InSolution™Blebbistatin, Racemic - Calbiochem

InSolution™Blebbistatin, Racemic, is a 50 mM in 90% DMSO. A cell-permeable, selective, and reversible inhibitor of nonmuscle myosin II. Blocks cell blebbing and disrupts cell migration & cytoKinesis.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: ATPase
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203389
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₈H₁₆N₂O₂

Pricing & Availability

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203389-5MG
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      		 Plastic ampoule 5 mg
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      Description
      Catalogue Number203389
      Brand Family Calbiochem®
      References
      ReferencesShu, S., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 1472.
      Kovacs, M., et al. 2004. J. Biol. Chem. 279, 35557.
      Straight, A.F., et al. 2003. Science 299, 1743.
      Cheung, A., et al. 2001. Mol. Biol. Cell Suppl. 12, 271a.
      Product Information
      ATP CompetitiveN
      FormLiquid
      FormulationA 50 mM (5 mg/342 µl) solution of (±)-Blebbistatin (Cat. No. 203390) in 90% DMSO.
      Hill FormulaC₁₈H₁₆N₂O₂
      Chemical formulaC₁₈H₁₆N₂O₂
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationInSolution™Blebbistatin, Racemic, is a 50 mM in 90% DMSO. A cell-permeable, selective, and reversible inhibitor of nonmuscle myosin II. Blocks cell blebbing and disrupts cell migration & cytoKinesis.
      Biological Information
      Primary TargetATPase
      Primary Target IC<sub>50</sub><100 µM inhibiting the ATPase and gliding motility of human platelets
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Harmful & Carcinogenic / Teratogenic
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      203389-5MG 04055977221251

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      InSolution™Blebbistatin, Racemic - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      InSolution™Blebbistatin, Racemic - Calbiochem Certificates of Analysis

      TitleLot Number
      203389

      References

      Reference overview
      Shu, S., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 1472.
      Kovacs, M., et al. 2004. J. Biol. Chem. 279, 35557.
      Straight, A.F., et al. 2003. Science 299, 1743.
      Cheung, A., et al. 2001. Mol. Biol. Cell Suppl. 12, 271a.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision20-May-2008 RFH
      DescriptionA cell-permeable compound that acts as a selective, potent, and reversible inhibitor of non-muscle myosin II. Inhibits the ATPase and gliding motility of human platelets (≤100 µM) without affecting myosin light chain kinase (MLCK) activity. Has been shown to block cell blebbing and to rapidly disrupt directed cell migration and cytokinesis in vertebrate cells. Does not disrupt mitosis or affect contractile ring assembly.
      FormLiquid
      FormulationA 50 mM (5 mg/342 µl) solution of (±)-Blebbistatin (Cat. No. 203390) in 90% DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₈H₁₆N₂O₂
      Structure formulaStructure formula
      Purity≥97% by HPLC
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Harmful & Carcinogenic / Teratogenic
      ReferencesShu, S., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 1472.
      Kovacs, M., et al. 2004. J. Biol. Chem. 279, 35557.
      Straight, A.F., et al. 2003. Science 299, 1743.
      Cheung, A., et al. 2001. Mol. Biol. Cell Suppl. 12, 271a.