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178497 Apoptosis Activator VII, Apoptozole - CAS 1054543-47-3 - Calbiochem

The Apoptosis Activator VII, Apoptozole, also referenced under CAS 1054543-47-3, modulates Apoptosis. This small molecule/inhibitor is primarily used for Cancer applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(4-Carboxamidobenzyl)-2-(3,5-bis-trifluoromethyl)-4,5-bis-(4-methoxyphenyl)-imidazole, Hsp70 Inhibitor III

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178497
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Overview

Key Spec Table

CAS #Empirical Formula
1054543-47-3C₃₃H₂₄F₆N₃O₃

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178497-10MG
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      Description
      OverviewA cell-permeable imidazole compound that directly binds anti-apoptotic chaperone Hsc70 and its inducible homologue Hsp70 (Kd = 210 and 140 nM, respectively). Apoptozole is shown to effectively inhibit the proliferation of SK-OV-3, HCT-15, and A549 cancer cell lines (IC50 = 220, 250 and 130 nM, respectively) and induce 90% apoptotic cell death in P19 embryonic carcinoma and A549 lung cancer cultures after 12 hours drug treatment (1 µM).
      Catalogue Number178497
      Brand Family Calbiochem®
      SynonymsN-(4-Carboxamidobenzyl)-2-(3,5-bis-trifluoromethyl)-4,5-bis-(4-methoxyphenyl)-imidazole, Hsp70 Inhibitor III
      References
      ReferencesCho, H.J., et al. 2012. J. Am. Chem. Soc. 133, 20267.
      Williams, D.R., et al. 2008. Angew. Chem. Int. Ed. 47, 7466.
      Product Information
      CAS number1054543-47-3
      FormWhite solid
      Hill FormulaC₃₃H₂₄F₆N₃O₃
      Chemical formulaC₃₃H₂₄F₆N₃O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥95% by HPLC
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      178497-10MG 04055977204827