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361564 GSK-3 Inhibitor XXIII, 3F8 - CAS 159109-11-2 - Calbiochem

The GSK-3 Inhibitor XXIII, 3F8, also referenced under CAS 159109-11-2, controls the biological activity of GSK-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphoryl

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Synonyms: 5-Ethyl-7,8-dimethoxy-1H-pyrrolo[3,4-c]-isoquinoline-1,3-(2H)-dione

361564
  
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      Overview

      Key Spec Table

      CAS #Empirical Formula
      159109-11-2C₁₅H₁₄N₂O₄
      Description
      OverviewA cell-permeable maleimide compound that acts as a potent, reversible, and ATP-competitive inhibitor against GSK-3β (Cat. No. 361524) activity (IC50 = 34, 67 and 304 nM in the presence of 10, 30 and 100 µM ATP, respectively), while exhibiting much reduced activity against Cdk2/A, KDR (71% and 53% inhibition, respectively, at 5µM inhibitor concentration), and a panel of 19 other kinases (IC50 >5 µM). Shown to potently activate cellular Wnt pathway and increase β-catenin-dependent reporter transcription (by 15-fold at 4 µM) in 293T cultures in vitro and, when applied at or prior to the shield stage of embryo, interfere with zebrafish forebrain development in vivo.
      Catalogue Number361564
      Brand Family Calbiochem®
      Synonyms5-Ethyl-7,8-dimethoxy-1H-pyrrolo[3,4-c]-isoquinoline-1,3-(2H)-dione
      References
      ReferencesZou, H., et al. 2010. J. Med. Chem. 53, 994.
      Zhong, H., et al. 2009. Mol. BioSyst. 5, 1356.
      Product Information
      CAS number159109-11-2
      FormYellow solid
      Hill FormulaC₁₅H₁₄N₂O₄
      Chemical formulaC₁₅H₁₄N₂O₄
      Structure formula ImageStructure formula Image
      Biological Information
      Purity≥95% by HPLC
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      361564 0