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178278 Apigenin - CAS 520-36-5 - Calbiochem

Induces the reversion of transformed phenotypes of v-H-ras-transformed NIH 3T3 cells at low concentration (12.5 µM).

Apigenin - CAS 520-36-5 - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: 4ʹ,5,7-Trihydroxyflavone

Primary Target: MAP kinase
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178278
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
520-36-5C₁₅H₁₀O₅

Precios y disponibilidad

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      Description
      OverviewInduces the reversion of transformed phenotypes of v-H-ras-transformed NIH 3T3 cells at low concentration (12.5 µM). This finding has been attributed to the inhibition of MAP kinase activity. Inhibits the proliferation of malignant tumor cells by G2/M arrest and induces morphological differentiation.
      Catalogue Number178278
      Brand Family Calbiochem®
      Synonyms4ʹ,5,7-Trihydroxyflavone
      References
      ReferencesKuo, M.L., and Yang, N.C. 1995. Biochem. Biophys. Res. Commun. 212, 767.
      Chaumontet, C., et al. 1994. Carcinogenesis 15, 2325.
      Kuo, M.L., et al. 1994. Cancer Lett. 87, 91.
      Sato, F., et al. 1994. Biochem. Biophys. Res. Commun. 204, 578.
      Product Information
      CAS number520-36-5
      ATP CompetitiveN
      FormYellow crystalline solid
      Hill FormulaC₁₅H₁₀O₅
      Chemical formulaC₁₅H₁₀O₅
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMAP kinase
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSLK9276000
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 36-26

      Wear suitable protective clothing.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 4 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      178278-5MG 04055977222425

      Documentation

      Licencias necesarias

      Título
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      Apigenin - CAS 520-36-5 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Apigenin - CAS 520-36-5 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      178278

      Referencias bibliográficas

      Visión general referencias
      Kuo, M.L., and Yang, N.C. 1995. Biochem. Biophys. Res. Commun. 212, 767.
      Chaumontet, C., et al. 1994. Carcinogenesis 15, 2325.
      Kuo, M.L., et al. 1994. Cancer Lett. 87, 91.
      Sato, F., et al. 1994. Biochem. Biophys. Res. Commun. 204, 578.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-March-2009 RFH
      Synonyms4ʹ,5,7-Trihydroxyflavone
      DescriptionA plant flavonoid that reverses the transformed phenotypes of various ras-transformed cells, apparently due to inhibition of mitogen activated protein (MAP) kinase-associated signal transduction pathways. Treatment of v-H-ras-transformed NIH 3T3 cells with apigenin (12.5 µM) has been shown to induce dephosphorylation of p44mapk and reduction in MAP kinase activity. Has also been reported to inhibit the proliferation of malignant tumor cells by G2/M arrest and to induce morphological differentiation.
      FormYellow crystalline solid
      CAS number520-36-5
      RTECSLK9276000
      Chemical formulaC₁₅H₁₀O₅
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml) or hot Ethanol (1 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 4 months at -20°C.
      Toxicity Irritant
      Merck USA index14, 730
      ReferencesKuo, M.L., and Yang, N.C. 1995. Biochem. Biophys. Res. Commun. 212, 767.
      Chaumontet, C., et al. 1994. Carcinogenesis 15, 2325.
      Kuo, M.L., et al. 1994. Cancer Lett. 87, 91.
      Sato, F., et al. 1994. Biochem. Biophys. Res. Commun. 204, 578.