482100 Sigma-AldrichL-NIL, Dihydrochloride - Calbiochem
A cell-permeable, potent and selective inhibitor of nitric oxide synthase that exhibits about 28-fold greater selectivity for inducible nitric oxide synthase than for the rat brain constitutive enzyme
More>> A cell-permeable, potent and selective inhibitor of nitric oxide synthase that exhibits about 28-fold greater selectivity for inducible nitric oxide synthase than for the rat brain constitutive enzyme Less<<Synonyms: L-N⁶-(1-Iminoethyl)lysine, DiHCl
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Overview
Key Spec Table
Empirical Formula |
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C₈H₁₇N₃O₂ · 2HCl |
Description | |
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Overview | This product has been discontinued. A cell-permeable, potent and selective inhibitor of nitric oxide synthase that exhibits about 28-fold greater selectivity for inducible nitric oxide synthase (IC50 = 3.3 µM) than for the rat brain constitutive enzyme (IC50 = 92 µM). Exhibits about 10-fold greater inhibitory potency than NG-Monomethyl-L-arginine (L-NMMA; Cat. No. 475886) in inhibiting γ-interferon-induced NO2- production (IC50 = 460 nM). |
Catalogue Number | 482100 |
Brand Family | Calbiochem® |
Synonyms | L-N⁶-(1-Iminoethyl)lysine, DiHCl |
Product Information | |
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ATP Competitive | N |
Form | White solid |
Hill Formula | C₈H₁₇N₃O₂ · 2HCl |
Chemical formula | C₈H₁₇N₃O₂ · 2HCl |
Hygroscopic | Hygroscopic |
Reversible | N |
Structure formula Image |
Biological Information | |
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Primary Target | iNOS |
Primary Target IC<sub>50</sub> | 3.3 µM against inducible nitric oxide synthase |
Purity | ≥98% by TLC |
Physicochemical Information | |
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Cell permeable | Y |
Global Trade Item Number | |
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Catalogue Number | GTIN |
482100 | 0 |