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482100 L-NIL, Dihydrochloride - Calbiochem

A cell-permeable, potent and selective inhibitor of nitric oxide synthase that exhibits about 28-fold greater selectivity for inducible nitric oxide synthase than for the rat brain constitutive enzyme

L-NIL, Dihydrochloride - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: L-N⁶-(1-Iminoethyl)lysine, DiHCl

Primary Target: iNOS
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      Overview

      Key Spec Table

      Empirical Formula
      C₈H₁₇N₃O₂ · 2HCl
      Description
      Overview

      This product has been discontinued.



      A cell-permeable, potent and selective inhibitor of nitric oxide synthase that exhibits about 28-fold greater selectivity for inducible nitric oxide synthase (IC50 = 3.3 µM) than for the rat brain constitutive enzyme (IC50 = 92 µM). Exhibits about 10-fold greater inhibitory potency than NG-Monomethyl-L-arginine (L-NMMA; Cat. No. 475886) in inhibiting γ-interferon-induced NO2- production (IC50 = 460 nM).
      Catalogue Number482100
      Brand Family Calbiochem®
      SynonymsL-N⁶-(1-Iminoethyl)lysine, DiHCl
      References
      ReferencesMoore, W.M., et al. 1996. J. Med. Chem. 39, 669.
      Connor, J.R., et al. 1995. Eur. J. Pharmacol. 273, 15.
      Stenger, S., et al. 1995. Eur. J. Pharmacol. 294, 703.
      Moore, W.M., et al. 1994. J. Med. Chem. 37, 3886.
      Stuehr, D.J., and Griffith, O.W. 1992. Adv. Enzymol. 65, 287.
      Product Information
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₈H₁₇N₃O₂ · 2HCl
      Chemical formulaC₈H₁₇N₃O₂ · 2HCl
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Biological Information
      Primary TargetiNOS
      Primary Target IC<sub>50</sub>3.3 µM against inducible nitric oxide synthase
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableY
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for 3 months at 4°C.
      Global Trade Item Number
      Catalogue Number GTIN
      482100 0