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07-1396 Anti-PP-1B Antibody

This Anti-PP-1B Antibody is validated for use in WB for the detection of PP-1B.

Anti-PP-1B Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Kinases & Phosphatases Gene Symbol: PPP1CB, PP-1B, PPP1CD UniProt Number: P62140
07-1396
100 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWBRbSerumPolyclonal Antibody
      Description
      Catalogue Number07-1396
      DescriptionAnti-PP-1B Antibody
      Alternate Names
      • protein phosphatase 1, catalytic subunit, beta
      • protein phosphatase 1, catalytic subunit, beta isoform
      • protein phosphatase 1, catalytic subunit, delta isoform
      • protein phosphatase 1-beta
      • protein phosphatase 1-delta
      • serine/threonine protein phosphatase PP1-beta catalytic subunit
      Background InformationType 1 protein Ser/Thr phosphatases (PP1) have a high specific activity against phosphorylase, and are resistant to okadaic acid up to concentrations of 50 nM, but sensitive to Inhibitor-2 and microcystin LR.
      References
      Product Information
      FormatSerum
      Control
      • Hek293 cell lysate
      PresentationUnpurified rabbit serum with 0.05% sodium azide.
      Applications
      ApplicationThis Anti-PP-1B Antibody is validated for use in WB for the detection of PP-1B.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human PP-1B.
      EpitopeN/A
      HostRabbit
      SpecificityThis antibody recognizes PP-1B.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq]
      Gene Symbol
      • PPP1CB
      • PP-1B
      • PPP1CD
      Purification MethodUnpurified
      UniProt Number
      UniProt SummaryFUNCTION: Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity.

      COFACTOR: Binds 1 iron ion per subunit (By similarity). & Binds 1 manganese ion per subunit (By similarity).

      SIZE: 327 amino acids; 37187 Da

      SUBUNIT: PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. PPP1R12A and PPP1R12B mediate binding to myosin. PPP1R3A, PPP1R3B, PPP1R3C and PPP1R3D mediate binding to glycogen (By similarity). Interacts with PPP1R7.

      SUBCELLULAR LOCATION: Cytoplasm (By similarity).

      SIMILARITY: Belongs to the PPP phosphatase family. PP-1 subfamily.
      Molecular Weight 37 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in Hek293 cell lysate.

      Western Blot Analysis: A 1:1,000 dilution of this antibody detected PP-1B on 10 µg of Hek293 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      07-1396 04053252367335

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies