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MABF213 Anti- STING, clone 41 Antibody

This Anti- STING, clone 41 Antibody is validated for use in Western Blotting and Flow Cytometry for the detection of STING.

Anti- STING, clone 41 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Research Sub-Category: Immunoglobulins & Immunology Gene Symbol: Tmem173, Eris Mita, Mpys, Sting UniProt Number: Q3TBT3
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MABF213
100 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MWB, FCRPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABF213
      DescriptionAnti- STING, clone 41 Antibody
      Alternate Names
      • Stimulator of interferon genes protein
      • mSTING
      • Endoplasmic reticulum interferon stimulator
      • ERIS
      • Mediator of IRF3 activation
      • MMITA
      • Transmembrane protein 173
      • STING
      Background InformationSTING, also known as mSTING, or Endoplasmic reticulum interferon stimulator, ERIS, Mediator of IRF3 activation, MMITA or Transmembrane protein 173, and encoded by the gene Tmem 173/Eris/Mita/Mpys/Sting, is a facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferons. STING acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol. Upon binding STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. STING also mediates cell death signaling via the activation of the ERK pathway. STING is found in multiple intracellular locations including the endoplasmic reticulum, plasma cell membrane, mitochondrion outer membrane, and perinuclear regions. STING is expressed in the B-cell lineage both immature and mature B cells but not plasma cells. Mutations in STING cause defects in innate immunity and compromised immune health.
      References
      Product Information
      FormatPurified
      PresentationPurified rat monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti- STING, clone 41 Antibody is validated for use in Western Blotting and Flow Cytometry for the detection of STING.
      Key Applications
      • Western Blotting
      • Flow Cytometry
      Application NotesFlow Cytometry Analysis: 2 µg of this antibody detected STING in mouse splenocyte cells.
      Biological Information
      ImmunogenRecombinant protein corresponding to the cytoplasmic domain of mouse STING.
      EpitopeCytoplasmic domain
      Clone41
      Concentration0.5 mg/mL
      HostRat
      IsotypeIgMκ
      Species Reactivity
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Tmem173
      • Eris Mita
      • Mpys
      • Sting
      UniProt Number
      Molecular Weight~42 kDa observed. Uniprot describes 2 isoforms produced by alternative splicing at ~38 kDa and ~48 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in RAW264.7 cell lysate.

      Western Blotting Analysis: A 1:2,000 dilution of this antibody detected STING in 10 µg of RAW264.7 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABF213 04053252983641

      Documentation

      Anti- STING, clone 41 Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti- STING, clone 41 Antibody Certificates of Analysis

      TitleLot Number
      Anti-STING, Clone 41 - 4144412 4144412
      Anti-STING, clone 41 - Q2442272 Q2442272
      Anti-STING, clone 41 - 3173815 3173815
      Anti-STING, clone 41 - 3211117 3211117
      Anti-STING, clone 41 - 3277584 3277584
      Anti-STING, clone 41 - 3542492 3542492
      Anti-STING, clone 41 - 3596849 3596849
      Anti-STING, clone 41 - 3750070 3750070
      Anti-STING, clone 41 - 3795306 3795306
      Anti-STING, clone 41 - 3919686 3919686
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