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373402 Hedgehog Antagonist VIII - CAS 330796-24-2 - Calbiochem

The Hedgehog Antagonist VIII, also referenced under CAS 330796-24-2, controls the biological activity of Hedgehog. This small molecule/inhibitor is primarily used for Cell Signaling applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Hh Signaling Antagonist VIII, 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-((3-(4-fluorophenyl)-3,4-dihydro-4-oxo-2-quinazolinyl)methyl)-urea

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373402
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
330796-24-2C₂₃H₁₅ClF₄N₄O₂

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373402-5MG
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      Description
      OverviewA cell-permeable quinazolinyl-urea compound that is shown to potently inhibit OCT-Shh-stimulated Gli transcription activity in a 10t1/2(s12) cell-based Luciferase reporter assay (IC50 = 70 nM).
      Catalogue Number373402
      Brand Family Calbiochem®
      SynonymsHh Signaling Antagonist VIII, 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-((3-(4-fluorophenyl)-3,4-dihydro-4-oxo-2-quinazolinyl)methyl)-urea
      References
      ReferencesBrunton, A.A., et al. 2008. J. Med. Chem. 51, 1108.
      Product Information
      CAS number330796-24-2
      FormClear slightly yellow solid
      Hill FormulaC₂₃H₁₅ClF₄N₄O₂
      Chemical formulaC₂₃H₁₅ClF₄N₄O₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C0. Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      373402-5MG 04055977191127

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      Hedgehog Antagonist VIII - CAS 330796-24-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Hedgehog Antagonist VIII - CAS 330796-24-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      373402

      References

      Reference overview
      Brunton, A.A., et al. 2008. J. Med. Chem. 51, 1108.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision23-December-2009 RFH
      SynonymsHh Signaling Antagonist VIII, 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-((3-(4-fluorophenyl)-3,4-dihydro-4-oxo-2-quinazolinyl)methyl)-urea
      DescriptionA cell-permeable quinazolinyl-urea compound that is shown to potently inhibit OCT-Shh-stimulated Gli transcription activity in a 10t1/2(s12) cell-based Luciferase reporter assay (IC50 = 70 nM).
      FormClear slightly yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number330796-24-2
      Chemical formulaC₂₃H₁₅ClF₄N₄O₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C0. Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBrunton, A.A., et al. 2008. J. Med. Chem. 51, 1108.