Millipore Sigma Vibrant Logo

AB1258 Anti-Cytochrome P450 Enzyme CYP1A1 Antibody

View Products on Sigmaaldrich.com
AB1258
100 µL  
Prix en cours de récupération
Le prix n'a pas pu être récupéré
La quantité minimale doit être un multiple de
Maximum Quantity is
À la validation de la commande Plus d'informations
Vous avez sauvegardé ()
 
Demander le prix
Disponibilité limitée
Disponibilité limitée
En stock 
Interrompu(e)
Disponible en quantités limitées
Disponibilité à confirmer
    Pour le restant : Nous vous tiendrons informé
      Pour le restant : Nous vous tiendrons informé
      Nous vous tiendrons informé
      Contacter le Service Clients
      Contact Customer Service

      Offres spéciales

       

      Contacter le Service Clients

      Aperçu

      Replacement Information

      Offres spéciales

      Tableau de caractéristiques principal

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIHC, WBRbSerumPolyclonal Antibody
      Description
      Catalogue NumberAB1258
      ReplacesMAB3522
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Cytochrome P450 Enzyme CYP1A1 Antibody
      References
      Product Information
      FormatSerum
      PresentationRabbit antiserum. Liquid, no preservatives.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Cytochrome P450 Enzyme CYP1A1 Antibody detects level of Cytochrome P450 Enzyme CYP1A1 & has been published & validated for use in IH & WB.
      Key Applications
      • Immunohistochemistry
      • Western Blotting
      Application NotesWestern blot

      Immunohistochemistry

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenSynthetic peptide
      HostRabbit
      SpecificityReacts with human cytochrome P450 CYP1A1 in human placental microsomal fraction and to recombinant human CYP1A1.
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.
      Gene Symbol
      • CYP1A1
      • CP11
      • P1-450
      • CYPIA1
      • P450-C
      • CYP1
      • P450DX
      • P450-P1
      • AHRR
      • AHH
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P04798 # Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
      SIZE: 512 amino acids; 58165 Da
      SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
      TISSUE SPECIFICITY: Lung, lymphocytes and placenta.
      SIMILARITY: SwissProt: P04798 ## Belongs to the cytochrome P450 family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      AB1258 04053252581472

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      Anti-Cytochrome P450 Enzyme CYP1A1 Antibody FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Anti-Cytochrome P450 Enzyme CYP1A1 Antibody Certificats d'analyse

      TitreNuméro de lot
      RABBIT ANTI-HUMAN CYTOCHROME P450 CYP1A1 POLYCLONAL ANTIBODY - 2119729 2119729
      RABBIT ANTI-HUMAN CYTOCHROME P450 CYP1A1 POLYCLONAL ANTIBODY - 2411809 2411809
      RABBIT ANTI-HUMAN CYTOCHROME P450 CYP1A1 - 3754730 3754730
      RABBIT ANTI-HUMAN CYTOCHROME P450 CYP1A1 - 3862519 3862519
      RABBIT ANTI-HUMAN CYTOCHROME P450 CYP1A1 - 4201317 4201317
      RABBIT ANTI-HUMAN CYTOCHROME P450 CYP1A1 -2681213 2681213
      RABBIT ANTI-HUMAN CYTOCHROME P450 CYP1A1 -2695211 2695211
      RABBIT ANTI-HUMAN CYTOCHROME P450 CYP1A1 -2855526 2855526
      RABBIT ANTI-HUMAN CYTOCHROME P450 CYP1A1 -2858474 2858474
      RABBIT ANTI-HUMAN CYTOCHROME P450 CYP1A1 -2891085 2891085

      Références bibliographiques

      Aperçu de la référence bibliographiqueApplicationEspèceNº PubMed
      A selective aryl hydrocarbon receptor modulator 3,3'-Diindolylmethane inhibits gastric cancer cell growth.
      Yin, XF; Chen, J; Mao, W; Wang, YH; Chen, MH
      Journal of experimental & clinical cancer research : CR  31  46  2011

      Afficher le résumé
      22592002 22592002
      Aryl hydrocarbon receptor pathway activation enhances gastric cancer cell invasiveness likely through a c-Jun-dependent induction of matrix metalloproteinase-9.
      Peng, TL; Chen, J; Mao, W; Song, X; Chen, MH
      BMC cell biology  10  27  2009

      Afficher le résumé Article en texte intégral
      19371443 19371443
      Elevated expression of CYP1A1 and gamma-SYNUCLEIN in human ectopic (ovarian) endometriosis compared with eutopic endometrium.
      Singh, MN; Stringfellow, HF; Taylor, SE; Ashton, KM; Ahmad, M; Abdo, KR; El-Agnaf, OM; Martin-Hirsch, PL; Martin, FL
      Molecular human reproduction  14  655-63  2008

      Afficher le résumé
      ImmunohistochemistryHuman18849443 18849443
      Expression of xenobiotic-metabolizing cytochrome P450 forms in human full-term placenta.
      Hakkola, J, et al.
      Biochem. Pharmacol., 51: 403-11 (1996)  1996

      8619884 8619884

      Produits & Applications associés

      Related Products

      Référence Description  
      AB10088 Anti-CYP450 1A1 Antibody Prix & Disponibilité
      AB10328 Anti-1A1 Antibody Prix & Disponibilité

      Catégories

      Life Science Research > Antibodies and Assays > Primary Antibodies