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538094 P18IN011 - CAS 77408-67-4 - Calbiochem

A cell-permeable, selective & direct blocker of p18-Cdk6 interaction. Inhibits p18INK4C protein activity & favors HSCs self-renewal by ~4.2-fold.

P18IN011 - CAS 77408-67-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1,2-Benzoxazol-3-yl-4-acetamidobenzenesulfonate, p18-Cdk6 Interaction Blocker, p18INK4C Inhibitor

Primary Target: p18
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
77408-67-4C₁₅H₁₂N₂O₅S

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      Description
      OverviewA cell-permeable benzoxazolyl-acetamidobenzenesulfonate compound that directly interacts with p18 protein and blocks its activity. Specifically disrupts p18-Cdk6 complex formation with no effect on p16-Cdk6 interaction. Shown to significantly expand HSCs long-term repopulating ability by ~4.2-fold and increase the frequency with an ED50 of 5.70 µM. Suggested to exert little influence through cell proliferation and apoptosis.

      Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
      Catalogue Number538094
      Brand Family Calbiochem®
      Synonyms1,2-Benzoxazol-3-yl-4-acetamidobenzenesulfonate, p18-Cdk6 Interaction Blocker, p18INK4C Inhibitor
      DescriptionP18IN011
      References
      ReferencesGao, Y., et al. 2015. Nat. Commun. 6, 6328.
      Product Information
      CAS number77408-67-4
      FormWhite solid
      Hill FormulaC₁₅H₁₂N₂O₅S
      Chemical formulaC₁₅H₁₂N₂O₅S
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetp18
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      5.38094.0001 04054839059285

      Documentation

      P18IN011 - CAS 77408-67-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Gao, Y., et al. 2015. Nat. Commun. 6, 6328.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision23-August-2016 JSW
      Synonyms1,2-Benzoxazol-3-yl-4-acetamidobenzenesulfonate, p18-Cdk6 Interaction Blocker, p18INK4C Inhibitor
      DescriptionA cell-permeable benzoxazolyl-acetamidobenzenesulfonate compound that directly interacts with p18 protein and blocks its activity. Specifically disrupts p18-Cdk6 complex formation with no effect on p16-Cdk6 interaction. Shown to significantly expand HSCs long-term repopulating ability by ~4.2-fold and increase the frequency with an ED50 of 5.70 µM. Suggested to exert little influence through cell proliferation and apoptosis.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number77408-67-4
      Chemical formulaC₁₅H₁₂N₂O₅S
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesGao, Y., et al. 2015. Nat. Commun. 6, 6328.