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MAB3291 Anti-H-Ras Antibody, clone 7D7.2

This Anti-H-Ras Antibody, clone 7D7.2 is validated for use in ELISA, WB for the detection of H-Ras.

Anti-H-Ras Antibody, clone 7D7.2 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: MAP Kinases Gene Symbol: HRAS, c-bas/has, H-Ras-1, RASH1, Ha-Ras, K-ras, N-ras, p21ras, c-H-ras, H-RasIDX, CTLO, HRAS1 UniProt Number: P01112
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MAB3291
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RELISA, WBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMAB3291
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-H-Ras Antibody, clone 7D7.2
      References
      Product Information
      FormatPurified
      Presentation0.02M phosphate buffer, 0.25M NaCl, pH 7.6, 0.1% sodium azide
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-H-Ras Antibody, clone 7D7.2 is validated for use in ELISA, WB for the detection of H-Ras.
      Key Applications
      • ELISA
      • Western Blotting
      Application NotesWestern blot

      ELISA

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenFull-length recombinant human H-Ras - GST fusion protein
      Clone7D7.2
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityRecognizes H-Ras (the oncogene of Harvey murine sarcoma virus). Approximate molecular weight of 21 kDa.
      IsotypeIgG2b
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • HRAS
      • c-bas/has
      • H-Ras-1
      • RASH1
      • Ha-Ras
      • K-ras
      • N-ras
      • p21ras
      • c-H-ras
      • H-RasIDX
      • CTLO
      • HRAS1
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P01112 # Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
      SIZE: 189 amino acids; 21298 Da
      SUBUNIT: In its GTP-bound form interacts with PLCE1. Interacts with TBC1D10C. Interacts with RGL3 (By similarity).
      SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor. Note=Shuttles between the plasma membrane and the Golgi apparatus.
      PTM: Palmitoylated by the ZDHHC9-GOLGA7 complex. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi.
      DISEASE: SwissProt: P01112 # Defects in HRAS are the cause of Costello syndrome [MIM:218040]; also known as faciocutaneoskeletal syndrome. Costello syndrome is a rare condition characterized by prenatally increased growth, postnatal growth deficiency, mental retardation, distinctive facial appearance, cardiovascular abnormalities (typically pulmonic stenosis, hypertrophic cardiomyopathy and/or atrial tachycardia), tumor predisposition, skin and musculoskeletal abnormalities. & Mutations which change positions 12, 13 or 61 activate the potential of c-ras to transform cultured cells and are implicated in a variety of human tumors. & Defects in HRAS are a cause of bladder cancer [MIM:109800]. & Defects in HRAS are also the cause of oral squamous cell carcinoma (OSCC).
      SIMILARITY: SwissProt: P01112 ## Belongs to the small GTPase superfamily. Ras family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8°C in undiluted aliquots for up to 6 months.

      WARNING: The monoclonal reagent solution contains 0.1% sodium azide as a preservative. Due to potential hazards arising from the build up of this material in pipes, spent reagent should be disposed of with liberal volumes of water.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MAB3291 04053252317897

      Documentation

      Anti-H-Ras Antibody, clone 7D7.2 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-H-Ras Antibody, clone 7D7.2 Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-(H)-RAS 3031653
      MOUSE ANTI-(H)-RAS - 2530118 2530118
      MOUSE ANTI-(H)-RAS - 3766792 3766792
      MOUSE ANTI-(H)-RAS - 3862673 3862673
      MOUSE ANTI-(H)-RAS -2570209 2570209
      MOUSE ANTI-(H)-RAS MONOCLONAL ANTIBODY - 2430506 2430506
      MOUSE ANTI-(H)-RAS MONOCLONAL ANTIBODY - 2446759 2446759
      MOUSE ANTI-(H)-RAS MONOCLONAL ANTIBODY - 2042771 2042771
      MOUSE ANTI-(H)-RAS MONOCLONAL ANTIBODY - 2165835 2165835
      MOUSE ANTI-(H)-RAS MONOCLONAL ANTIBODY - 2278489 2278489
      Show more

      References

      Reference overviewPub Med ID
      Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors.
      Sasaki, AT; Carracedo, A; Locasale, JW; Anastasiou, D; Takeuchi, K; Kahoud, ER; Haviv, S; Asara, JM; Pandolfi, PP; Cantley, LC
      Science signaling  4  ra13  2011

      Show Abstract       		21386094 21386094

      Data Sheet

      Title
      MOUSE ANTI-(H)-RAS MONOCLONAL ANTIBODY

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      Categories

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