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190080 AY 9944 - CAS 366-93-8 - Calbiochem

A cell-permeable amphiphilic diamine that blocks cholesterol biosynthesis and its esterification.

AY 9944 - CAS 366-93-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: trans-1,4-bis(2-Chlorobenzylaminomethyl)cyclohexane, 2HCl, Shh Signaling Antagonist IV

Primary Target: 7-dehydrocholesterol reductase (δ7-sterol reductase)
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190080
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
366-93-8C₂₂H₂₈Cl₂N₂ • 2HCl

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      Description
      OverviewA cell-permeable amphiphilic diamine that blocks cholesterol biosynthesis and its esterification. Specifically blocks 7-dehydrocholesterol reductase (Δ7-sterol reductase) activity with IC50= 13 nM. Important tool in Sonic Hedgehog signaling and teratogenicity studies. Also reported to induce a rapid and irreversible reduction in Acidic-Sphingomyelinase activity in fibroblasts.
      Catalogue Number190080
      Brand Family Calbiochem®
      Synonymstrans-1,4-bis(2-Chlorobenzylaminomethyl)cyclohexane, 2HCl, Shh Signaling Antagonist IV
      References
      ReferencesGofflot, F., et al. 2001. Dev. Dyn. 220, 99.
      Cooper, M.K., et al. 1998. Science 280, 1603.
      Incardona, J.P., et al. 1998. Development 125, 3553.
      Moebius, F.F., et al. 1998. Proc. Natl. Acad. Sci. USA95, 1899.
      Yoshida, Y. 1985. J. Biochem. 98, 1669.
      Kraml, M., et al. 1964. Biochem. Biophys. Res. Commun. 15, 455.
      Product Information
      CAS number366-93-8
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₂H₂₈Cl₂N₂ • 2HCl
      Chemical formulaC₂₂H₂₈Cl₂N₂ • 2HCl
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Target7-dehydrocholesterol reductase (δ7-sterol reductase)
      Primary Target IC<sub>50</sub>13 nM in blocking 7-dehydrocholesterol reductase (δ7-sterol reductase) activity
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSGU7025000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful & Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      190080-5MG 04055977221336

      Documentation

      AY 9944 - CAS 366-93-8 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      AY 9944 - CAS 366-93-8 - Calbiochem Certificates of Analysis

      TitleLot Number
      190080

      References

      Reference overview
      Gofflot, F., et al. 2001. Dev. Dyn. 220, 99.
      Cooper, M.K., et al. 1998. Science 280, 1603.
      Incardona, J.P., et al. 1998. Development 125, 3553.
      Moebius, F.F., et al. 1998. Proc. Natl. Acad. Sci. USA95, 1899.
      Yoshida, Y. 1985. J. Biochem. 98, 1669.
      Kraml, M., et al. 1964. Biochem. Biophys. Res. Commun. 15, 455.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-October-2007 JSW
      Synonymstrans-1,4-bis(2-Chlorobenzylaminomethyl)cyclohexane, 2HCl, Shh Signaling Antagonist IV
      DescriptionA cell-permeable, amphiphilic diamine that acts as a potent inhibitor of cholesterol biosynthesis and esterification and exhibits teratogenic properties. Specifically blocks 7-dehydro-cholesterol reductase (Δ7-sterol reductase; DHC) activity with IC50= 13 nM. Reported to disrupt Sonic Hedgehog (Shh) signaling during embryogenesis in rats. Also reported to induce a rapid and irreversible reduction in acidic-sphingomyelinase activity in fibroblasts.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number366-93-8
      RTECSGU7025000
      Chemical formulaC₂₂H₂₈Cl₂N₂ • 2HCl
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityH₂O (20 mg/ml) or DMSO (20 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful & Carcinogenic / Teratogenic
      ReferencesGofflot, F., et al. 2001. Dev. Dyn. 220, 99.
      Cooper, M.K., et al. 1998. Science 280, 1603.
      Incardona, J.P., et al. 1998. Development 125, 3553.
      Moebius, F.F., et al. 1998. Proc. Natl. Acad. Sci. USA95, 1899.
      Yoshida, Y. 1985. J. Biochem. 98, 1669.
      Kraml, M., et al. 1964. Biochem. Biophys. Res. Commun. 15, 455.