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317240 Metformin - CAS 1115-70-4 - Calbiochem

Metformin, CAS 1115-70-4, lowers blood glucose levels without stimulating insulin secretion. Stimulates AMPK leading to the reduction in acetyl-CoA carboxylase (ACC) activity.

Metformin - CAS 1115-70-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1,1-Dimethylbiguanide, Hydrochloride, AMPK Signaling Activator VII

Primary Target: AMP-activated protein kinase (AMPK)
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317240
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1115-70-4C₄H₁₁N₅ • HCl

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      Description
      OverviewAn antihyperglycemic agent that lowers blood glucose levels without stimulating insulin secretion, promoting weight gain or causing hypoglycemia. Reported to stimulate AMP-activated protein kinase (AMPK) leading to the reduction in acetyl-CoA carboxylase (ACC) activity and induction of fatty acid oxidation.
      Catalogue Number317240
      Brand Family Calbiochem®
      Synonyms1,1-Dimethylbiguanide, Hydrochloride, AMPK Signaling Activator VII
      References
      ReferencesCleasby, M.E., et al. 2004. Diabetes 53, 3258.
      Klein, J., et al. 2004. J. Endocrinol. 183, 299.
      Zhou, G., et al. 2001. J. Clin. Invest. 108, 1167.
      Lin, H.Z., et al. 2000. Nat. Med. 6, 998.
      Product Information
      CAS number1115-70-4
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₄H₁₁N₅ • HCl
      Chemical formulaC₄H₁₁N₅ • HCl
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationMetformin, CAS 1115-70-4, lowers blood glucose levels without stimulating insulin secretion. Stimulates AMPK leading to the reduction in acetyl-CoA carboxylase (ACC) activity.
      Biological Information
      Primary TargetAMP-activated protein kinase (AMPK)
      Purity≥97% by Titration
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSDU1800000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +15°C to +30°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      317240-5GM 04055977216196

      Documentation

      Metformin - CAS 1115-70-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Metformin - CAS 1115-70-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      317240

      References

      Reference overview
      Cleasby, M.E., et al. 2004. Diabetes 53, 3258.
      Klein, J., et al. 2004. J. Endocrinol. 183, 299.
      Zhou, G., et al. 2001. J. Clin. Invest. 108, 1167.
      Lin, H.Z., et al. 2000. Nat. Med. 6, 998.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-May-2008 RFH
      Synonyms1,1-Dimethylbiguanide, Hydrochloride, AMPK Signaling Activator VII
      DescriptionAn anti-hyperglycemic agent that acts by lowering the hepatic output of glucose. Does not stimulate insulin secretion, promote weight gain, or cause hypoglycemia. Reported to stimulate AMP-activated protein kinase (AMPK), leading to the reduction in acetyl-CoA carboxylase (ACC) activity and induction of fatty acid oxidation.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1115-70-4
      RTECSDU1800000
      Chemical formulaC₄H₁₁N₅ • HCl
      Structure formulaStructure formula
      Purity≥97% by Titration
      SolubilityH₂O (50 mg/ml)
      Storage +15°C to +30°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Irritant
      Merck USA index14, 5938
      ReferencesCleasby, M.E., et al. 2004. Diabetes 53, 3258.
      Klein, J., et al. 2004. J. Endocrinol. 183, 299.
      Zhou, G., et al. 2001. J. Clin. Invest. 108, 1167.
      Lin, H.Z., et al. 2000. Nat. Med. 6, 998.