500496 Sigma-AldrichPorcn Inhibitor II, C59 - CAS 1243243-89-1 - Calbiochem
More>>
Less<<
Primary Target:
Porcupine (Porcn)-mediated Wnt palmitoylation
FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Synonymes: Wnt-C59, Wnt Pathway Inhibitor XVI, 2-(4-(2-Methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide
Produits recommandés
Aperçu
| Replacement Information |
|---|
Tableau de caractéristiques principal
| CAS # | Empirical Formula |
|---|---|
| 1243243-89-1 | C₂₅H₂₁N₃O |
Prix & Disponibilité
| Référence | Disponibilité | Conditionnement | Qté | Prix | Quantité | |
|---|---|---|---|---|---|---|
| 5.00496.0001 |
|
Flacon en verre | 10 mg |
|
— | |
| 5.00496.0002 |
|
Flacon en verre |
|
— |
| Description | |
|---|---|
| Overview | A cell-permeable pyridinylphenyl-acetamide that is much more potent than IWP-2 (Cat. No. 681671) in inhibiting MBOAT family member Porcupine-mediated Wnt palmitoylation (IC50 = 74 pM in STF reporter assays using Wnt3a-transfected HEK293). Shown to be effective against Porcn of murine and human, but not xenopus, species and potently inhibit the processing of both canonical and non-canonical Wnt subtypes. C59 is demonstrated to be orally active and effectively suppress MMTV-WNT1 tumor expansion in mice (5 mg/kg & 10 mg/kg p.o.) in vivo. Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water. |
| Catalogue Number | 500496 |
| Brand Family | Calbiochem® |
| Synonyms | Wnt-C59, Wnt Pathway Inhibitor XVI, 2-(4-(2-Methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide |
| References | |
|---|---|
| References | Proffitt, K.D., et al. 2013. Cancer Res. 73, 502. |
| Product Information | |
|---|---|
| CAS number | 1243243-89-1 |
| Form | Off-white powder |
| Hill Formula | C₂₅H₂₁N₃O |
| Chemical formula | C₂₅H₂₁N₃O |
| Reversible | Y |
| Quality Level | MQ100 |
| Applications |
|---|
| Biological Information | |
|---|---|
| Primary Target | Porcupine (Porcn)-mediated Wnt palmitoylation |
| Purity | ≥99% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Dimensions |
|---|
| Materials Information |
|---|
| Toxicological Information |
|---|
| Safety Information according to GHS |
|---|
| Safety Information |
|---|
| Product Usage Statements |
|---|
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
|---|
| Supplemental Information |
|---|
| Specifications |
|---|
| Global Trade Item Number | |
|---|---|
| Référence | GTIN |
| 5.00496.0001 | 04055977245615 |
| 5.00496.0002 | 04054839067495 |
Documentation
Porcn Inhibitor II, C59 - CAS 1243243-89-1 - Calbiochem FDS
| Titre |
|---|
Références bibliographiques
| Aperçu de la référence bibliographique |
|---|
| Proffitt, K.D., et al. 2013. Cancer Res. 73, 502. |
| Fiche technique | ||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
|