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509706 DFB - CAS 15332-10-2 - Calbiochem

A positive allosteric modulator for mGlu receptor subtype 5 (EC₅₀ = 2 - 5.3 µM).

DFB - CAS 15332-10-2 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: [(3-Fluorophenyl)methylene]hydrazone-3-fluorobenzaldehyde, 3,3ʹ-Difluorobenzaldazine

Primary Target: mGlu₅
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      15332-10-2C₁₄H₁₀F₂N₂
      Description
      Overview

      This product has been discontinued.



      A positive allosteric modulator for mGlu receptor subtype 5 (EC50 = 2 - 5.3 µM). No agonistic action on mGlu5. Renders 3-6 fold potentiation for Glu5 agonists. No effect on other mGlu receptor subtypes.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number509706
      Brand Family Calbiochem®
      Synonyms[(3-Fluorophenyl)methylene]hydrazone-3-fluorobenzaldehyde, 3,3ʹ-Difluorobenzaldazine
      References
      ReferencesOʹBrien, J., et al. 2003. Mol. Pharmacol. 64, 731.
      Zhang Z., et al. 2005. J. Pharmacol. Exp. Ther. 315, 1212.
      Product Information
      CAS number15332-10-2
      FormYellow solid
      Hill FormulaC₁₄H₁₀F₂N₂
      Chemical formulaC₁₄H₁₀F₂N₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetmGlu₅
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      509706 0

      Documentation

      DFB - CAS 15332-10-2 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Références bibliographiques

      Aperçu de la référence bibliographique
      OʹBrien, J., et al. 2003. Mol. Pharmacol. 64, 731.
      Zhang Z., et al. 2005. J. Pharmacol. Exp. Ther. 315, 1212.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision14-February-2014 JSW
      Synonyms[(3-Fluorophenyl)methylene]hydrazone-3-fluorobenzaldehyde, 3,3ʹ-Difluorobenzaldazine
      DescriptionA positive allosteric modulator for mGlu receptor subtype 5 (EC50 = 2 - 5.3 µM). No agonistic action on mGlu5. Renders 3-6 fold potentiation for Glu5 agonists. No effect on other mGlu receptor subtypes.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number15332-10-2
      Chemical formulaC₁₄H₁₀F₂N₂
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (12 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesOʹBrien, J., et al. 2003. Mol. Pharmacol. 64, 731.
      Zhang Z., et al. 2005. J. Pharmacol. Exp. Ther. 315, 1212.