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MAB3786-C Anti-APC Antibody, CT, clone C-APC Antibody 28.9, Ascites Free

Anti-APC Antibody, CT, clone C-APC Antibody 28.9, Ascites Free is an antibody against APC for use in Immunohistochemistry (Paraffin), Immunocytochemistry, Immunofluorescence, Western Blotting.

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Research Category: Epigenetics & Nuclear Function Research Sub-Category: Cell Cycle, DNA Replication & Repair Gene Symbol: APC, DP2.5 UniProt Number: P25054
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MAB3786-C
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      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIH(P), ICC, IF, WBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMAB3786-C
      DescriptionAnti-APC Antibody, CT, clone C-APC Antibody 28.9, Ascites Free
      Alternate Names
      • Adenomatous polyposis coli protein
      • Deleted in polyposis 2.5
      • Protein APC
      Background InformationAdenomatous polyposis coli protein (UniProt P25054; also known as Deleted in polyposis 2.5, Protein APC) is encoded by the APC (also known as DP2.5) gene (Gene ID 324) in human. The multifunctional tumor suppressor APC is a large scaffold protein that contains multiple armadillo repeat (ARM) domains (a.a. 453-767 of human APC spliced isoform 1) for mediating various cellular functions, including Wnt signal regulation, cell adhesion, and chromosomal segregation during mitosis. APC, AXIN, casein kinase 1 (CK1) and glycogen synthase kinase 3 (GSK3) constitute the core proteins of the β-catenin destruction complex that functions as the negative regulator against Wnt signaling transduction. Mice with Apc gene mutations develop adenomas in the intestine due to Wnt hyperactivation, and functional loss of APC due to gene mutations is the hallmark of human colorectal cancers (CRC). APC also directs cholinergic synapse assembly between neurons and is commonly employed as a marker for monitoring stem cells neuronal differentiation.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-APC Antibody, CT, clone C-APC Antibody 28.9, Ascites Free is an antibody against APC for use in Immunohistochemistry (Paraffin), Immunocytochemistry, Immunofluorescence, Western Blotting.
      Key Applications
      • Immunohistochemistry (Paraffin)
      • Immunocytochemistry
      • Immunofluorescence
      • Western Blotting
      Application NotesImmunohistochemistry Analysis: A 1:250 dilution from a representative lot detected APC in human kidney and cardiac muscle.
      Immunocytochemistry Analysis: A representative detected an increased APC expression in human eyelid adipose-derived stem cells (hEASCs) after neuroinduction at passage 8 (Zhou, J., et al. (2014). J. Cell. Mol. Med. 18(2):326-343).
      Immunofluorescence Analysis: A representative lot detected a granular APC staining pattern at a subapical region of epithelial cells in fallopian mucosa by fluorescent immunohistochemistry staining of paraffin-embedded, paraformaldehyd-fixed fallopian tube tissue sections (Kessler, M., et al. (2012). Am. J. Pathol. 180(1):186-198).
      Biological Information
      ImmunogenHuman APC C-terminal fusion with MBP (maltose binding protein).
      EpitopeC-terminal region.
      CloneC-APC 28.9
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityRecognizes human APC, molecular weight is approximately 310 kDa.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • APC
      • DP2.5
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight311.6 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceImmunohistochemistry Analysis: A 1:250 dilution from a representative lot detected APC in human cerebral cortex tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      MAB3786-C 04055977334203

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      Categorías

      Life Science Research > Antibodies and Assays > Primary Antibodies