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GF442-MG HumanKine® TNF alpha, Human Recombinant Xeno-Free

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
UniProt Number: P01375
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GF442-MG
1mg  
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      Overview

      Replacement Information

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      Bulk Size Quantities of HumanKine Growth Factors are Available.
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      Key Spec Table

      SourcePurity
      HumanKine growth factors are expressed in a proprietary human 293 protein expression system and are manufactured without the use of any animal products and are considered Xeno-Free.Product is endotoxin free (<0.1 ng/μg of protein (<1 EU/μg) and greater than 95% pure by SDS-PAGE.
      Description
      Catalogue NumberGF442-MG
      Trade Name
      • HumanKine®
      DescriptionHumanKine® TNF alpha, Human Recombinant Xeno-Free
      Alternate Names
      • Tumor Necrosis Factor-α
      • TNFa
      Background InformationTumor necrosis factor alpha (TNF-α), is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that plays a central role in inflammation, apoptosis, and immune system development. TNF-α is produced by a wide variety of immune and epithelial cell types. It belongs to the TNF family of ligands and signals through two receptors, TNFR1 and TNFR2. TNF-α is cytotoxic to a wide variety of tumor cells and is an essential factor in mediating the immune response against bacterial infections. TNF-α also plays a role in the induction of septic shock, auto immune diseases, rheumatoid arthritis, inflammation, and diabetes.
      References
      Product Information
      Formulation
      PresentationProduct is presented in PBS and filtered through a 0.2 micron filter before lyophilization.
      Quality LevelMQ100
      Applications
      Biological Information
      PurityProduct is endotoxin free (<0.1 ng/μg of protein (<1 EU/μg) and greater than 95% pure by SDS-PAGE.
      SourceHumanKine growth factors are expressed in a proprietary human 293 protein expression system and are manufactured without the use of any animal products and are considered Xeno-Free.
      UniProt Number
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceBioactivity assay: Determined by the dose-dependent cytotoxity of the TNF alpha sensitive cell line L-929 in the presence of
      Actinomycin D. Typically < 0.9 ng/mL ED50.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at -20°C for up to 4 months from date of receipt. Further dilutions should be made into appropriate buffer or medium to which protein has been added.
      Packaging Information
      Material Size1mg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      GF442-MG 04053252961656