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344845 Fumagillin, Aspergillus fumigatus - CAS 23110-15-8 - Calbiochem

Antiprotozoal agent and angiogenesis inhibitor.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Fumidil B, MetAP-2 Inhibitor I, MetAP2 Inhibitor I, Methionine Aminopeptidase 2 Inhibitor I

Primary Target: Methionine amino-peptidase 2
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344845
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
23110-15-8C₂₆H₃₄O₇

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344845-500UG
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      		 Plastic ampoule 500 μg
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      Description
      OverviewAntiprotozoal agent and angiogenesis inhibitor. Acts as an inhibitor of methionine amino-peptidase 2.
      Catalogue Number344845
      Brand Family Calbiochem®
      SynonymsFumidil B, MetAP-2 Inhibitor I, MetAP2 Inhibitor I, Methionine Aminopeptidase 2 Inhibitor I
      References
      ReferencesZhang, P., et al. 2002. J. Biomed. Sci. 9, 34.
      Stepien, H., et al. 1996. J. Endocrinol. 150, 99.
      Abrams, J.S., et al. 1994. Cancer 74, 1164.
      Jenkins, D.C., et al. 1993. Br. J. Cancer 68, 856.
      Le Querrec, A., et al. 1993. Baillieres Clin. Hematol. 6, 711.
      Molnar, K. 1993. Acta Vet. Hung. 41, 51.
      Kusada, M., et al. 1991. Biochem. Biophys. Res. Commun. 174, 1070.
      Brackett, J.M., et al. 1988. J. Agric. Food Chem. 36, 762.
      Product Information
      CAS number23110-15-8
      ATP CompetitiveN
      FormWhite to off-white powder
      Hill FormulaC₂₆H₃₄O₇
      Chemical formulaC₂₆H₃₄O₇
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMethionine amino-peptidase 2
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSHE1750000
      Safety Information
      R PhraseR: 22

      Harmful if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      344845-500UG 04055977214857

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      Fumagillin, Aspergillus fumigatus - CAS 23110-15-8 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Fumagillin, Aspergillus fumigatus - CAS 23110-15-8 - Calbiochem Certificates of Analysis

      TitleLot Number
      344845

      References

      Reference overview
      Zhang, P., et al. 2002. J. Biomed. Sci. 9, 34.
      Stepien, H., et al. 1996. J. Endocrinol. 150, 99.
      Abrams, J.S., et al. 1994. Cancer 74, 1164.
      Jenkins, D.C., et al. 1993. Br. J. Cancer 68, 856.
      Le Querrec, A., et al. 1993. Baillieres Clin. Hematol. 6, 711.
      Molnar, K. 1993. Acta Vet. Hung. 41, 51.
      Kusada, M., et al. 1991. Biochem. Biophys. Res. Commun. 174, 1070.
      Brackett, J.M., et al. 1988. J. Agric. Food Chem. 36, 762.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-July-2017 JSW
      SynonymsFumidil B, MetAP-2 Inhibitor I, MetAP2 Inhibitor I, Methionine Aminopeptidase 2 Inhibitor I
      DescriptionAn inhibitor of angiogenesis. Has selective cytostatic effects against ras transformed cells (IC50 = 10 pM). Antiprotozoal agent active against sporozoan parasites in bees and myxozoan parasites in fish.
      FormWhite to off-white powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number23110-15-8
      RTECSHE1750000
      Chemical formulaC₂₆H₃₄O₇
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityMethanol (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Harmful
      Merck USA index14, 4286
      ReferencesZhang, P., et al. 2002. J. Biomed. Sci. 9, 34.
      Stepien, H., et al. 1996. J. Endocrinol. 150, 99.
      Abrams, J.S., et al. 1994. Cancer 74, 1164.
      Jenkins, D.C., et al. 1993. Br. J. Cancer 68, 856.
      Le Querrec, A., et al. 1993. Baillieres Clin. Hematol. 6, 711.
      Molnar, K. 1993. Acta Vet. Hung. 41, 51.
      Kusada, M., et al. 1991. Biochem. Biophys. Res. Commun. 174, 1070.
      Brackett, J.M., et al. 1988. J. Agric. Food Chem. 36, 762.