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ABF191-25UL Anti-FcRn (FCGRT)

This rabbit polyclonal Anti-FcRn (FCGRT) antibody, Cat. No. ABF191, detects IgG receptor FcRn large subunit p51. It has been tested for use in Immunofluorescence and Western Blotting.

Anti-FcRn (FCGRT) MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Gene Symbol: Fcgrt, Fcrn UniProt Number: Q61559
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ABF191-25UL
25 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MIF, WBRbPurifiedPolyclonal Antibody
      Description
      Catalogue NumberABF191-25UL
      DescriptionAnti-FcRn (FCGRT)
      Alternate Names
      • IgG receptor FcRn large subunit p51
      • IgG Fc fragment receptor transporter alpha chain
      • Neonatal Fc receptor
      Background InformationIgG receptor FcRn large subunit p51 (UniProt: Q61559; also known as FcRn, IgG Fc fragment receptor transporter alpha chain, Neonatal Fc receptor) is encoded by the Fcgrt (also known as Fcrn) gene (Gene ID: 14132) in murine species. FcRn is a single-pass type I membrane protein that binds to the Fc region of monomeric immunoglobulins gamma. FcRn complex consist of two subunits: p51 and p14 and contains one Ig-like C1-type (immunoglobulin-like) domain of 88 amino acids. FcRn mediates the selective uptake of IgG from milk and helps newborn animals to acquire passive immunity. In rodents, FcRn functions effectively in the neonatal period when it transports maternally derived IgG in ingested milk across the epithelial-cell layer of the proximal small intestine. However, in humans it transports maternal antibody to the fetus across the placenta. In rodent FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. FcRn also protects IgG from degradation providing long half-life of this class of antibody in the serum. (Ref.: Roopenian,, DC and Shreeram,, A (2007). Nat. Rev. Immunol. 7(9); 715-725).
      References
      Product Information
      FormatPurified
      PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationThis rabbit polyclonal Anti-FcRn (FCGRT) antibody, Cat. No. ABF191, detects IgG receptor FcRn large subunit p51. It has been tested for use in Immunofluorescence and Western Blotting.
      Key Applications
      • Immunofluorescence
      • Western Blotting
      Application NotesImmunofluorescence Analysis: A representative lot detected FcRn (FCGRT) in mouse uterus and vagina (Li, Z., et. al. (2011). Proc Natl Acad Sci USA. 108(11):4388-93).

      Western Blotting Analysis: A representative lot detected FcRn (FCGRT) in mouse liver, mouse uterus, and vagina tissue lysate (Li, Z., et. al. (2011). Proc Natl Acad Sci USA. 108(11):4388-93).
      Biological Information
      ImmunogenGST-tagged recombinant fragment corresponding to 44 amino acids from the C-terminal region of murine IgG receptor FcRn large subunit p51.
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityThis polyclonal antibody detects murine IgG receptor FcRn. It targets an epitope within 44 amino acids from the C-terminal region.
      IsotypeIgG
      Species Reactivity
      • Mouse
      Species Reactivity NoteMouse.
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • Fcgrt
      • Fcrn
      Purification MethodAffinity Purified
      UniProt Number
      Molecular Weight53 kDa observed. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in mouse liver tissue lysate.
      Western Blotting Analysis: A 1:500 dilution of this antibody detected FcRn (FCGRT) in 10 µg of m ouse liver tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size25 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABF191-25UL 04054839480140