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28745 Adenosine 3ʹ,5ʹ-cyclic Monophosphate, N⁶,O2ʹ-Dibutyryl-, Sodium Salt - CAS 16980-89-5 - Calbiochem

This Dibutyryl-cAMP, CAS 16980-89-5, is a cell-permeable cAMP analog that preferentially activates PKA.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Dibutyryl-cAMP, Na

Primary Target: PKA
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28745
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Overview

Key Spec Table

CAS #Empirical Formula
16980-89-5C₁₈H₂₃N₅O₈P · Na

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28745-100MG
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      28745-25MG
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          Description
          OverviewA cell-permeable cAMP analog that preferentially activates cAMP-dependent protein kinase (PKA). Causes an increase in the steady state level of parathyroid hormone-related peptide mRNA. Also acts as a Hh pathway antagonist. Shown to induce apoptosis in vascular smooth muscle cells.
          Catalogue Number28745
          Brand Family Calbiochem®
          SynonymsDibutyryl-cAMP, Na
          References
          ReferencesNoveen, A., et al. 1996. Biochem. Biophys. Res. Commun. 219, 180.
          Tsai, C.H., et al. 1995. J. Cell. Physiol. 164, 108.
          Leszczynski, D., et al. 1994. Am. J. Pathol. 145, 1265.
          Miller, C., et al. 1994. J. Neurosci. Res. 38, 56.
          Hinko, A., and Soloff, M.S. 1993. Endocrinology 132, 126.
          Ikeda, K., et al. 1993. J. Biol. Chem. 268, 1174.
          Park, E.A., et al. 1993. J. Biol. Chem. 268, 613.
          Hei, Y-J., et al. 1991. Mol. Pharmacol. 39, 233.
          Posternak, T., and Weimann, G. 1974. Methods Enzymol. 38, 399.
          Product Information
          CAS number16980-89-5
          ATP CompetitiveN
          FormWhite lyophilized solid
          Hill FormulaC₁₈H₂₃N₅O₈P · Na
          Chemical formulaC₁₈H₂₃N₅O₈P · Na
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ200
          Biological Information
          Primary TargetPKA
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Safety Information according to GHS
          RTECSES5055500
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Aqueous stock solutions are stable for up to 3 days at 4°C or for up to 3 months at -20°C. Avoid pH >8.5.
          Global Trade Item Number
          Catalogue Number GTIN
          28745-100MG 04055977197839
          28745-25MG 04055977090970