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251800 Daunorubicin, Hydrochloride - CAS 23541-50-6 - Calbiochem

Potent cell-permeable anticancer agent whose potential target site may be mitochondrial cytochrome c oxidase.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Daunomycin, HCl

Primary Target: DNA synthesis, RNA synthesis
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      23541-50-6C₂₇H₂₉NO₁₀ · HCl
      Description
      OverviewPotent cell-permeable anticancer agent whose potential target site may be mitochondrial cytochrome c oxidase. Has been shown to inhibit RNA and DNA synthesis. Inhibits eukaryotic topoisomerases I and II. Induces DNA single-strand breaks. Also induces apoptosis in HeLa S3 tumor cells.
      Catalogue Number251800
      Brand Family Calbiochem®
      SynonymsDaunomycin, HCl
      References
      ReferencesFriedenberg, W.R., et al. 1995. Am. J. Clin. Oncol. 18, 105.
      Papadopoulou, L.C., and Tsiftsoglou, A.S. 1993. Cancer Res. 53, 1072.
      Skladanowski, A., and Konopa, J. 1993. Biochem. Pharmacol. 46, 375.
      Wolff, M., and Jelkmann, W. 1993. Ann. Hematol. 66, 27.
      Bellec, F., et al. 1992. Flow Cytometry 13, 880.
      Product Information
      CAS number23541-50-6
      ATP CompetitiveN
      FormRed crystalline solid
      Hill FormulaC₂₇H₂₉NO₁₀ · HCl
      Chemical formulaC₂₇H₂₉NO₁₀ · HCl
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetDNA synthesis, RNA synthesis
      PurityPotency: ≥840 µg/mg
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSHB7878000
      Safety Information
      R PhraseR: 22-40-42/43

      Harmful if swallowed.
      Limited evidence of a carcinogenic effect.
      May cause sensitization by inhalation and skin contact.
      S PhraseS: 22-36/37-45

      Do not breathe dust.
      Wear suitable protective clothing and gloves.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful & Carcinogenic / Teratogenic
      Storage +15°C to +30°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 1 month at 4°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      251800 0

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      Daunorubicin, Hydrochloride - CAS 23541-50-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Daunorubicin, Hydrochloride - CAS 23541-50-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      251800

      References

      Reference overview
      Friedenberg, W.R., et al. 1995. Am. J. Clin. Oncol. 18, 105.
      Papadopoulou, L.C., and Tsiftsoglou, A.S. 1993. Cancer Res. 53, 1072.
      Skladanowski, A., and Konopa, J. 1993. Biochem. Pharmacol. 46, 375.
      Wolff, M., and Jelkmann, W. 1993. Ann. Hematol. 66, 27.
      Bellec, F., et al. 1992. Flow Cytometry 13, 880.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-June-2008 RFH
      SynonymsDaunomycin, HCl
      DescriptionPotent cell-permeable anticancer agent whose potential target site may be mitochondrial cytochrome C oxidase. Has been shown to inhibit RNA and DNA synthesis and to intercalate into DNA. Inhibits eukaryotic topoisomerase I and II. Induces DNA single strand breaks. Induces apoptosis in HeLaS3 tumor cells.
      FormRed crystalline solid
      CAS number23541-50-6
      RTECSHB7878000
      Chemical formulaC₂₇H₂₉NO₁₀ · HCl
      Structure formulaStructure formula
      PurityPotency: ≥840 µg/mg
      SolubilityAqueous buffers, H₂O, or Methanol
      Storage +15°C to +30°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 1 month at 4°C.
      Toxicity Harmful & Carcinogenic / Teratogenic
      Merck USA index14, 2832
      ReferencesFriedenberg, W.R., et al. 1995. Am. J. Clin. Oncol. 18, 105.
      Papadopoulou, L.C., and Tsiftsoglou, A.S. 1993. Cancer Res. 53, 1072.
      Skladanowski, A., and Konopa, J. 1993. Biochem. Pharmacol. 46, 375.
      Wolff, M., and Jelkmann, W. 1993. Ann. Hematol. 66, 27.
      Bellec, F., et al. 1992. Flow Cytometry 13, 880.