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ABS1035 Anti-FMO2 Antibody

Detect FMO2 using this Anti-FMO2 Antibody validated for use in Western Blotting, Immunohistochemistry.

Anti-FMO2 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Toxicology & Drug Resistance Gene Symbol: FMO2, FMO1B1 UniProt Number: Q99518
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ABS1035
200 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, IHCRbSerumPolyclonal Antibody
      Description
      Catalogue NumberABS1035
      DescriptionAnti-FMO2 Antibody
      Alternate Names
      • Dimethylaniline monooxygenase [N-oxide-forming] 2
      • Dimethylaniline oxidase 2
      • FMO 1B1
      • Pulmonary flavin-containing monooxygenase 2
      • FMO 2
      Background InformationDimethylaniline monooxygenase [N-oxide-forming] 2 (EC 1.14.13.8; UniProt Q99518; also known as Dimethylaniline oxidase 2, FMO 1B1, FMO 2, Pulmonary flavin-containing monooxygenase 2) is encoded by the FMO2 (also known as FMO1B1) gene (Gene ID 2327) in human. Flavin monooxygenases (FMOs) are flavin-containing enzymes that catalyze substrates oxidation at the expense of NADPH and molecular oxygen. FMO2 is expressed in the lung tissue and therefore known as the pulmonary FMO. Two FMO2 alleles have been described in human. FMO2.1 is the functional full-length version that is found in high frequency in Sub-Saharan African populations (49%) and their Hispanic descendants (2-7%), whereas the FMO2.2 gene carries a C-to-T transition mutation that results in a premature stop codon (TAG), yielding a C-terminally truncated 64-amino acid non-functional protein FMO2X472 found in all Caucasians and Asians. Known human FMO2.1 substrates include sulfur-derived compounds such as thioureas, thioetherorganophosphates, thiazetazone and ethionamide.
      References
      Product Information
      FormatSerum
      PresentationRabbit polyclonal serum with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect FMO2 using this Anti-FMO2 Antibody validated for use in Western Blotting, Immunohistochemistry.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected FMO2 in mouse lung, mouse kidney, and human kidney tissue sections.
      Biological Information
      ImmunogenLinear peptide corresponding to an internal sequence from the N-terminal half of human FMO2.
      EpitopeInternal (N-terminal half).
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      Species Reactivity
      • Human
      • Mouse
      Species Reactivity NoteHuman, Mouse. Predicted to react with Chimpanzee, Orangutan based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • FMO2
      • FMO1B1
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~55 kDa observed. 53.64 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human liver microsomal lysate.

      Western Blotting Analysis: A 1:500 dilution of this antibody detected FMO2 in 10 µg of human liver microsomal lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABS1035 04055977315738