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124013 Akt Inhibitor VI, Akt-in - Calbiochem

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124013
  
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      Overview

      Key Spec Table

      Empirical Formula
      C₈₈H₁₂₃N₂₃O₂₃
      Description
      OverviewA reversible 15-mer peptide derived from proto-oncogene TCL1 (amino acids 10-24) that acts as a specific inhibitor of Akt. Shown to bind to Akt-PH domain (Kd ~18 µM) and interfere with the Akt-phosphoinositide interaction, thus hindering membrane translocation from the cytosol and downstream biological responses.
      Catalogue Number124013
      Brand Family Calbiochem®
      SynonymsTCL1₁₀₋₂₄, H-AVTDHPDRLWAWEKF-OH
      References
      ReferencesHiromura, M., et al. 2004. J. Biol. Chem. 279, 53407.
      Product Information
      ATP CompetitiveN
      FormWhite lyophilized solid
      FormulationSupplied as an acetate salt.
      Hill FormulaC₈₈H₁₂₃N₂₃O₂₃
      Chemical formulaC₈₈H₁₂₃N₂₃O₂₃
      Hygroscopic Hygroscopic
      ReversibleY
      Quality LevelMQ100
      Biological Information
      Primary TargetAkt
      Primary Target IC<sub>50</sub>Kd ~18 µM in binding to Akt-PH domain
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceH-Ala-Val-Thr-Asp-His-Pro-Asp-Arg-Leu-Trp-Ala-Trp-Glu-Lys-Phe-OH
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      124013 0