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203820 Guanosine 3ʹ,5ʹ-cyclic Monophosphate, 8-Bromo-, Sodium Salt - CAS 51116-01-9 - Calbiochem

Cell-permeable cGMP analog that is more resistant to phosphodiesterases than cGMP.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 8-Bromo-cGMP, Br-cGMP, Na

Primary Target: protein kinase G
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203820
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
51116-01-9C₁₀H₁₀BrN₅O₇P · Na

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203820-25MG
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      Description
      OverviewCell-permeable cGMP analog that is more resistant to phosphodiesterases than cGMP. Preferentially activates protein kinase G. Inhibits thrombin-stimulated arachidonic acid release in human platelets.
      Catalogue Number203820
      Brand Family Calbiochem®
      Synonyms8-Bromo-cGMP, Br-cGMP, Na
      References
      ReferencesKwak, B.R., and Jongsma, H.J. 1996. Mol. Cell. Biochem. 157, 93.
      Perreault, T., and DeMarte, J. 1993. Am. J. Physiol. 264, H302.
      Ruth, P., et al. 1991. Eur. J. Biochem. 202, 1339.
      Schwarzschild, M.A., and Zigmond, R.E. 1991. J. Neurochem. 56, 400.
      Product Information
      CAS number51116-01-9
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₀H₁₀BrN₅O₇P · Na
      Chemical formulaC₁₀H₁₀BrN₅O₇P · Na
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetprotein kinase G
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Moisture Protect from moisture
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 week at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      203820-25MG 04055977204032

      Documentation

      Guanosine 3ʹ,5ʹ-cyclic Monophosphate, 8-Bromo-, Sodium Salt - CAS 51116-01-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Guanosine 3ʹ,5ʹ-cyclic Monophosphate, 8-Bromo-, Sodium Salt - CAS 51116-01-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      203820

      References

      Reference overview
      Kwak, B.R., and Jongsma, H.J. 1996. Mol. Cell. Biochem. 157, 93.
      Perreault, T., and DeMarte, J. 1993. Am. J. Physiol. 264, H302.
      Ruth, P., et al. 1991. Eur. J. Biochem. 202, 1339.
      Schwarzschild, M.A., and Zigmond, R.E. 1991. J. Neurochem. 56, 400.

      Citations

      Title
    • Bing Zhu, Samuel Strada and Troy Stevens. (2005) Cyclic GMP-specific phosphodiesterase 5 regulates growth and apoptosis in pulmonary endothelial cells. American Journal of Physiology Lung Cellular and Molecular Physiology 289, L196-L206.
      		•
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision22-May-2008 RFH
      Synonyms8-Bromo-cGMP, Br-cGMP, Na
      DescriptionCell-permeable cGMP analog that is more resistant to phosphodiesterases than cGMP. Preferentially activates protein kinase G. Inhibits thrombin-stimulated arachidonic acid release in human platelets.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number51116-01-9
      Chemical formulaC₁₀H₁₀BrN₅O₇P · Na
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityH₂O (200 mg/ml)
      Storage Protect from moisture
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 week at -20°C.
      Toxicity Standard Handling
      ReferencesKwak, B.R., and Jongsma, H.J. 1996. Mol. Cell. Biochem. 157, 93.
      Perreault, T., and DeMarte, J. 1993. Am. J. Physiol. 264, H302.
      Ruth, P., et al. 1991. Eur. J. Biochem. 202, 1339.
      Schwarzschild, M.A., and Zigmond, R.E. 1991. J. Neurochem. 56, 400.
      Citation
    • Bing Zhu, Samuel Strada and Troy Stevens. (2005) Cyclic GMP-specific phosphodiesterase 5 regulates growth and apoptosis in pulmonary endothelial cells. American Journal of Physiology Lung Cellular and Molecular Physiology 289, L196-L206.
      		•