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189400 Aurintricarboxylic Acid - CAS 4431-00-9 - Calbiochem

A cell-permeable polyanionic, polyaromatic compound used as a powerful inhibitor of cellular processes that are dependent on the formation of protein-nucleic acid complexes.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: ATA

Primary Target: DNA topoisomerase 2
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189400
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
4431-00-9C₂₂H₁₄O₉

Pricing & Availability

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189400-100MG
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      		 Plastic ampoule 100 mg
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      Description
      OverviewA cell-permeable polyanionic, polyaromatic compound used as a powerful inhibitor of cellular processes that are dependent on the formation of protein-nucleic acid complexes. Binds to aFGF and reduces its angiogenic activity. Shown to inhibit apoptotic cell death in various cell types induced by a variety of factors. ATA is a potent inhibitor of DNA topoisomerase II (IC50= 75 nM for the yeast enzyme as measured by relaxation assays) that also acts as a potent inhibitor of angiogenesis. Inhibits von Willebrand factor binding to platelets and reduces glutamate-induced neuronal injury. ATA stimulates the tyrosine phosphorylation of MAP kinases, Shc proteins, phosphatidylinositol 3-kinase, and phospholipase Cγ. Inhibits both major calpain isoforms (IC50 = 22 µM and IC50 = 10 µM for µ-calpain and m-calpain, respectively).
      Dye content: ~85%.
      Catalogue Number189400
      Brand Family Calbiochem®
      SynonymsATA
      References
      ReferencesLozano, R.M., et al. 1997. Eur. J. Biochem. 248, 30.
      Benchokroun, Y., et al. 1995. Biochem. Pharmacol. 49, 305.
      Okada, N., and Koizumi, S. 1995. J. Biol. Chem. 270, 16464.
      Posner, A., et al. 1995. Biochem. Mol. Biol. Int. 36, 291.
      Catchpoole, D.R., et al. 1994. Anticancer Res. 14, 853.
      Csernansky, C.A., et al. 1994. J. Neurosci. Res. 38, 101.
      Gagliardi, A.R., and Collins, D.C. 1994. Anticancer Res. 14, 475.
      Gonzalez, R.G., et al. 1980. Biochemistry 19, 4299.
      Product Information
      CAS number4431-00-9
      ATP CompetitiveN
      FormRed solid
      Hill FormulaC₂₂H₁₄O₉
      Chemical formulaC₂₂H₁₄O₉
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetDNA topoisomerase 2
      Primary Target IC<sub>50</sub>75 nM against DNA topoisomerase II
      Purity≥85% by Titration
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSGU4790000
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      189400-100MG 04055977221725

      Documentation

      Aurintricarboxylic Acid - CAS 4431-00-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Aurintricarboxylic Acid - CAS 4431-00-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      189400

      References

      Reference overview
      Lozano, R.M., et al. 1997. Eur. J. Biochem. 248, 30.
      Benchokroun, Y., et al. 1995. Biochem. Pharmacol. 49, 305.
      Okada, N., and Koizumi, S. 1995. J. Biol. Chem. 270, 16464.
      Posner, A., et al. 1995. Biochem. Mol. Biol. Int. 36, 291.
      Catchpoole, D.R., et al. 1994. Anticancer Res. 14, 853.
      Csernansky, C.A., et al. 1994. J. Neurosci. Res. 38, 101.
      Gagliardi, A.R., and Collins, D.C. 1994. Anticancer Res. 14, 475.
      Gonzalez, R.G., et al. 1980. Biochemistry 19, 4299.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-April-2019 JSW
      SynonymsATA
      DescriptionA cell-permeable polyanionic, polyaromatic compound used as a powerful inhibitor of cellular processes that are dependent on the formation of protein-nucleic acid complexes. Shown to inhibit apoptotic cell death in various cell types induced by a variety of factors. ATA is also a potent inhibitor of DNA topoisomerase II. Inhibits von Willebrand factor binding to platelets and reduces glutamate-induced neuronal injury. ATA has been reported to stimulate the tyrosine phosphorylation of MAP kinases, Shc proteins, phosphatidylinositol 3-kinase, and phospholipase C-γ. Dye content: ~85%.
      FormRed solid
      CAS number4431-00-9
      RTECSGU4790000
      Chemical formulaC₂₂H₁₄O₉
      Structure formulaStructure formula
      Purity≥85% by Titration
      Solubility0.1 M NaOH (35 mg/ml)
      Storage +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Irritant
      ReferencesLozano, R.M., et al. 1997. Eur. J. Biochem. 248, 30.
      Benchokroun, Y., et al. 1995. Biochem. Pharmacol. 49, 305.
      Okada, N., and Koizumi, S. 1995. J. Biol. Chem. 270, 16464.
      Posner, A., et al. 1995. Biochem. Mol. Biol. Int. 36, 291.
      Catchpoole, D.R., et al. 1994. Anticancer Res. 14, 853.
      Csernansky, C.A., et al. 1994. J. Neurosci. Res. 38, 101.
      Gagliardi, A.R., and Collins, D.C. 1994. Anticancer Res. 14, 475.
      Gonzalez, R.G., et al. 1980. Biochemistry 19, 4299.