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119113 Luciferase Inhibitor I - CAS 352341-26-5 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
352341-26-5C₁₄H₁₁N₃O₂

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119113-5MG
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      Description
      OverviewA 3,5-diaryl-oxadiazole compound that acts as an inhibitor against the ATP-dependent Photuris pennsylvanica (lucPpe) and Photinus pyralis (lucPpy) luciferase activity (IC50 = 0.08 and 2.8 µM, respectively, with 10 µM ATP, 10 µM luciferin, and 10 nM respective enzyme) and effectively inhibits lucPpe-based commercial luciferase-luciferin formulations (IC50 = 5, 13.5, and 12.7 µM against Promega's Kinase-Glo®, Kinase-Glo® Plus, and Kinase-Glo® Max, respectively, at a 3-fold formulation dilution and 6.77 µM ATP). Unlike Luciferase Inhibitor II (Cat. No. 119114), Luciferase Inhibitor I is noncompetitive with respect to either luciferin or ATP.
      Catalogue Number119113
      Brand Family Calbiochem®
      Synonyms2-(5-(2-Methoxyphenyl)-1,2,4-oxadiazol-3-yl)pyridine
      References
      ReferencesAuld, D.S., et al. 2009. J. Med. Chem. 52, 1450.
      Auld, D.S., et al. 2008. J. Med. Chem. 51, 2372.
      Product Information
      CAS number352341-26-5
      DeclarationMarketed by Promega Corp. under the registered trademarks.
      FormOff-white solid
      Hill FormulaC₁₄H₁₁N₃O₂
      Chemical formulaC₁₄H₁₁N₃O₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥95% by HPLC
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      119113-5MG 04055977223231