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341207 ET-18-OCH₃ - CAS 70641-51-9 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
70641-51-9C₂₇H₅₈NO₆P

Pricing & Availability

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341207-50MG
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      341207-5MG
      Limited Availability
Limited Availability
      In Stock 
      Discontinued
      Limited Quantities Available
      Availability to be confirmed
        Remaining : Will advise
          Remaining : Will advise
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          Contact Customer Service
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          Description
          OverviewA cell-permeable and reversible cytotoxic agent that shows selective cytocidal activity against neoplastic cells and virally transformed cells. Selectively inhibits phosphatidylinositol-specific phospholipase C (PI-PLC, IC50 = 9.6 µM) but does not inhibit phosphatidylcholine-specific PLC or PLD. Promotes apoptosis in mitogen-activated, but not resting, T lymphocytes in a dose- and time-dependent manner. Also promotes rapid and selective apoptosis in human leukemic cells.
          Catalogue Number341207
          Brand Family Calbiochem®
          SynonymsEdelfosine, 1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphorylcholine
          References
          ReferencesHarguindey, J., et al. 2000. Apoptosis 5, 87.
          Cabaner, C., et al. 1999. Br. J. Pharmacol. 127, 813.
          Powis, G., and Phil, D. 1994. Cancer Metastasis Rev. 13, 91.
          Helfman, D., et al. 1993. Cancer Res. 53, 2955.
          Mollinedo, F., et al. 1993. Biochem. Biophys. Res. Commun. 192, 603.
          Powis, G., et al. 1992. Cancer Res. 52, 2835.
          Oishi, K., et al. 1988. Biochem. Biophys. Res. Commun. 157, 1000.
          Product Information
          CAS number70641-51-9
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₂₇H₅₈NO₆P
          Chemical formulaC₂₇H₅₈NO₆P
          ReversibleY
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Biological Information
          Primary TargetPI-PLC
          Primary Target IC<sub>50</sub>9.6 µM against phosphatidylinositol-specific phospholipase C (PI-PLC)
          Purity≥95% by TLC
          Physicochemical Information
          Cell permeableY
          Safety Information according to GHS
          RTECSYK0718000
          Safety Information
          R PhraseR: 40

          Limited evidence of a carcinogenic effect.
          S PhraseS: 22-36

          Do not breathe dust.
          Wear suitable protective clothing.
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution in ethanol, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 3 months at -20°C. Unstable in aqueous solution; reconstitute just prior to use.
          Global Trade Item Number
          Catalogue Number GTIN
          341207-50MG 04053252041402
          341207-5MG 04055977215441