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420107 Jasplakinolide, Jaspis johnstoni - CAS 102396-24-7 - Calbiochem

Jasplakinolide, Jaspis johnstoni, CAS 102396-24-7, is a cell-permeable F-actin probe. Induces actin polymerization and stabilization. Blocks activation of store-mediated Ca2+ entry into cells.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Primary Target: Inducer of actin polymerization and stabilization in vitro
420107
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
102396-24-7C₃₆H₄₅BrN₄O₆

Precios y disponibilidad

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      Description
      OverviewA cell-permeable F-actin probe. A cyclodepsipeptide with antifungal and antitumor properties. A potent inducer of actin polymerization and stabilization in vitro. Prevents activation of store-mediated Ca2+ entry into cells. It competes with Phalloidin (Cat. No. 516640) for actin binding (Kd = 15 nM) and enhances apoptosis induced by interleukin 2 (IL-2) deprivation. A 1 mM (50 µg/71 µl) solution of Jasplakinolide, Jaspis johnstoni (Cat. No. 420127) in DMSO is also available.
      Catalogue Number420107
      Brand Family Calbiochem®
      References
      ReferencesRosado, J.A., et al. 2000. J. Biol. Chem. 275, 7527.
      Posey, S.C., and Bierer, B.E. 1999. J. Biol. Chem. 274, 4259.
      Senderowicz, A.M., et al. 1995. J. Natl. Cancer Inst. 87, 46.
      Bubb, M.R., et al. 1994. J. Biol. Chem. 269, 14869.
      Scott, V.R., et al. 1988. Antimicrob. Agents Chemother. 32, 1154.
      Product Information
      CAS number102396-24-7
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₃₆H₄₅BrN₄O₆
      Chemical formulaC₃₆H₄₅BrN₄O₆
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationJasplakinolide, Jaspis johnstoni, CAS 102396-24-7, is a cell-permeable F-actin probe. Induces actin polymerization and stabilization. Blocks activation of store-mediated Ca2+ entry into cells.
      Biological Information
      Primary TargetInducer of actin polymerization and stabilization in vitro
      Primary Target IC<sub>50</sub>Kd = 15 nM for actin binding
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      420107-50UG 07790788050085

      Documentation

      Jasplakinolide, Jaspis johnstoni - CAS 102396-24-7 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Jasplakinolide, Jaspis johnstoni - CAS 102396-24-7 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      420107

      Referencias bibliográficas

      Visión general referencias
      Rosado, J.A., et al. 2000. J. Biol. Chem. 275, 7527.
      Posey, S.C., and Bierer, B.E. 1999. J. Biol. Chem. 274, 4259.
      Senderowicz, A.M., et al. 1995. J. Natl. Cancer Inst. 87, 46.
      Bubb, M.R., et al. 1994. J. Biol. Chem. 269, 14869.
      Scott, V.R., et al. 1988. Antimicrob. Agents Chemother. 32, 1154.

      Citas

      Título
    • Markus Utech, et al. (2005) Mechanism of IFN-γ-Induced Endocytosis of Tight Junction Proteins: Mysoin II-Dependent Vacuolarization of the Apical Plasma Membrane. Molecular Biology of the Cell 16, 5040-5052.
      		•
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision24-July-2008 RFH
      DescriptionA cell-permeable F-actin probe. This macrocyclic cyclodepsipeptide, isolated from the marine sponge Jaspis johnstoni, is a potent inducer of actin polymerization and stabilization in vitro. It competes with Phalloidin (Cat. No. 516640) for actin binding (Kd = 15 nM) and enhances apoptosis induced by interleukin 2 (IL-2) deprivation. Also displays fungicidal, insecticidal, and anticancer properties.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number102396-24-7
      Chemical formulaC₃₆H₄₅BrN₄O₆
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up 3 months at -20°C.
      Toxicity Harmful
      ReferencesRosado, J.A., et al. 2000. J. Biol. Chem. 275, 7527.
      Posey, S.C., and Bierer, B.E. 1999. J. Biol. Chem. 274, 4259.
      Senderowicz, A.M., et al. 1995. J. Natl. Cancer Inst. 87, 46.
      Bubb, M.R., et al. 1994. J. Biol. Chem. 269, 14869.
      Scott, V.R., et al. 1988. Antimicrob. Agents Chemother. 32, 1154.
      Citation
    • Markus Utech, et al. (2005) Mechanism of IFN-γ-Induced Endocytosis of Tight Junction Proteins: Mysoin II-Dependent Vacuolarization of the Apical Plasma Membrane. Molecular Biology of the Cell 16, 5040-5052.
      		•