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353905 Glutathione Monoethyl Ester - CAS 118421-50-4 - Calbiochem

Cell-permeable derivative of glutathione (GSH) that undergoes hydrolysis by intracellular esterases to release GSH.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: γ-GCE, L-γ-Glutamyl-L-cysteinyl Ethyl Glycinate, GSH-MEE

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353905
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
118421-50-4C₁₂H₂₁N₃O₆S

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353905-50MG
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      Description
      OverviewCell-permeable derivative of glutathione (GSH) that undergoes hydrolysis by intracellular esterases to release GSH. Effective transport of GSH-MEE has been used to protect cells against damage from radiation, oxidants, and various toxic compounds including heavy metals. A protective agent against cellular damage such as in cataracts and mitochondrial degeneration.
      Catalogue Number353905
      Brand Family Calbiochem®
      Synonymsγ-GCE, L-γ-Glutamyl-L-cysteinyl Ethyl Glycinate, GSH-MEE
      References
      ReferencesGrattagliano, I., et al. 1995. J. Pharmacol. Exp. Ther. 272, 484.
      Martensson, J., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 317.
      Anderson, M.E., and Meister, A. 1989. Anal. Biochem. 183, 16.
      Anderson, M.E., et al. 1985. Arch. Biochem. Biophys. 239, 538.
      Wellner, V.P., et al. 1984. Proc. Natl. Acad. Sci. USA 81, 4732.
      Puri, R.N., and Meister, A. 1983. Proc. Natl. Acad. Sci. USA 80, 5258.
      Product Information
      CAS number118421-50-4
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₂H₂₁N₃O₆S
      Chemical formulaC₁₂H₂₁N₃O₆S
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetEffective transport of GSH-MEE
      Purity>90% by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Unstable in solution; reconstitute just prior to use.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      353905-50MG 04055977193244

      Documentation

      Glutathione Monoethyl Ester - CAS 118421-50-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Glutathione Monoethyl Ester - CAS 118421-50-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      353905

      References

      Reference overview
      Grattagliano, I., et al. 1995. J. Pharmacol. Exp. Ther. 272, 484.
      Martensson, J., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 317.
      Anderson, M.E., and Meister, A. 1989. Anal. Biochem. 183, 16.
      Anderson, M.E., et al. 1985. Arch. Biochem. Biophys. 239, 538.
      Wellner, V.P., et al. 1984. Proc. Natl. Acad. Sci. USA 81, 4732.
      Puri, R.N., and Meister, A. 1983. Proc. Natl. Acad. Sci. USA 80, 5258.

      Brochure

      Title
      Pathways and Biomarkers of Oxidative Stress

      Citations

      Title
    • Teresa Sanchez Alcaraz, et al. (2004) Involvement of Glutathione as a Mechanism of Indirect Protection against Spontaneous Ex Vivo Apoptosis Associated with Bovine Leukemia Virus. Journal of Virology 78, 6180-6190.
      		•
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-July-2007 RFH
      Synonymsγ-GCE, L-γ-Glutamyl-L-cysteinyl Ethyl Glycinate, GSH-MEE
      DescriptionCell-permeable derivative of glutathione (GSH) that undergoes hydrolysis by intracellular esterases thereby increasing intracellular GSH concentration in many tissues and cell types. Effective transport of GSH-MEE has been used to protect cells against radiation damage, oxidants and various toxic compounds including heavy metals. A protective agent against cellular damage, such as cataracts and mitochondrial degeneration.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number118421-50-4
      Chemical formulaC₁₂H₂₁N₃O₆S
      Structure formulaStructure formula
      Purity>90% by TLC
      SolubilityH₂O (50 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Unstable in solution; reconstitute just prior to use.
      Toxicity Standard Handling
      ReferencesGrattagliano, I., et al. 1995. J. Pharmacol. Exp. Ther. 272, 484.
      Martensson, J., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 317.
      Anderson, M.E., and Meister, A. 1989. Anal. Biochem. 183, 16.
      Anderson, M.E., et al. 1985. Arch. Biochem. Biophys. 239, 538.
      Wellner, V.P., et al. 1984. Proc. Natl. Acad. Sci. USA 81, 4732.
      Puri, R.N., and Meister, A. 1983. Proc. Natl. Acad. Sci. USA 80, 5258.
      Citation
    • Teresa Sanchez Alcaraz, et al. (2004) Involvement of Glutathione as a Mechanism of Indirect Protection against Spontaneous Ex Vivo Apoptosis Associated with Bovine Leukemia Virus. Journal of Virology 78, 6180-6190.
      		•