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124008 Akt Inhibitor II - Calbiochem

Akt Inhibitor II, CAS 701976-54-7, is a cell permeable, reversible, and substrate competitive phosphatidylinositol analog that inhibits the activation of Akt & downstream substrates.

Akt Inhibitor II - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: SH-5

Primary Target: Akt
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124008
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Overview

Key Spec Table

Empirical Formula
C₂₉H₅₉O₁₀P

Pricing & Availability

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124008-1MG
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      Description
      OverviewA cell permeable, reversible, and substrate competitive phosphatidylinositol analog that inhibits the activation of Akt and select downstream substrates without decreasing phosphorylation of PDK-1 or other kinases downstream of Ras, such as MAPK. Also acts as a potent inducer of apoptosis and selectively kills a variety of cancer cell lines that contain high levels of active Akt. When used at a concentration of 10 µM, it is reported to activate p38α/SAPK2α MAP kinase. At 10 µM it will also inhibit ~50% of PKA activity.
      Catalogue Number124008
      Brand Family Calbiochem®
      SynonymsSH-5
      References
      ReferencesGills, J.J., et al. 2007. J. Biol. Chem. in press.
      Kozikowski, A.P., et al. 2003. J. Am. Chem. Soc.125, 1144.
      Product Information
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₉H₅₉O₁₀P
      Chemical formulaC₂₉H₅₉O₁₀P
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationAkt Inhibitor II, CAS 701976-54-7, is a cell permeable, reversible, and substrate competitive phosphatidylinositol analog that inhibits the activation of Akt & downstream substrates.
      Biological Information
      Primary TargetAkt
      Purity≥98% by NMR
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      124008-1MG 04055977206333