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420136 JNK Inhibitor IX - CAS 312917-14-9 - Calbiochem

The JNK Inhibitor IX, also referenced under CAS 312917-14-9, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applic

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Synonyms: N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-1-naphthamide

Primary Target: JNK2 and JNK3
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420136
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Overview

Key Spec Table

CAS #Empirical Formula
312917-14-9C₂₀H₁₆N₂OS • H₂O

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420136-5MG
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      Description
      OverviewA thienylnaphthamide compound that acts as a potent and ATP binding site-targeting inhibitor of JNK2 and JNK3 (pIC50 = 6.5 and 6.7, respectively) with little or no activity against JNK1, p38α, and a panel of more than 30 other kinases (pIC50 <5.0). In contrast, SP600125 (Cat. Nos. 420119 and 420128) offers little selectivity between JNK1 and JNK3 (pIC50 = 6.4 and 5.9, respectively) under the same assay conditions.
      Catalogue Number420136
      Brand Family Calbiochem®
      SynonymsN-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-1-naphthamide
      References
      ReferencesAngell, R.M., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1296.
      Product Information
      CAS number312917-14-9
      ATP CompetitiveY
      FormTan solid
      Hill FormulaC₂₀H₁₆N₂OS • H₂O
      Chemical formulaC₂₀H₁₆N₂OS • H₂O
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetJNK2 and JNK3
      Primary Target IC<sub>50</sub>pIC50 = 6.5 and 6.7, against JNK2 and JNK3, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36-45

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      420136-5MG 04055977187663