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533851 Cancer Stemness Inhibitor, BBI608 - CAS 83280-65-3 - Calbiochem

A cell-permeable compound that diminishes gene expression and self-renewal in stemness high cancer cells. Blocks cancer relapse and metastasis.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-Acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione, 2-Acetylnaphtho[2,3-b]furan-4,9-dione, Spherogenesis Blocker, BBI-608

Primary Target: STAT3
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533851
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Overview

Key Spec Table

CAS #Empirical Formula
83280-65-3C₁₄H₈O₄

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      		 Glass bottle 10 mg
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      Description
      OverviewA cell-permeable, bioactive, non-toxic naphthofurandione analog that blocks STAT3-driven gene transcription. Selectively diminishes gene expression and self-renewal in stemness high cancer cells. Shown to be more effective in stemness high cancer cell population (IC50 = 142 nM) compared to regular cancer cells (IC50 = 395 nM). Reduces spherogenesis in CD44 expressing cancer cells without affecting the colony formation in CD34+ hematopoietic stem cells. Effectively reduces the levels of Nanog, Axl, Sox-2, Klf4, survivin, c-Myc, Bmi-1, and β-catenin within a few hours following treatment. Displays broad spectrum activity against stemness high cancer cells from multiple tumors (IC50 = 291, 432, 624, 479, 549, and 729 nM for CAOV-3, SW-626, PaCa2, SNU-475, H1975, and U87-MG, respectively). Suppresses the growth of PaCa-2 xenografts in murine models that exhibited relapse of tumor growth (20 mg/kg, i.p, q.d.) following the cessation of 41-day gemcitabine treatment. Also shown to block cancer relapse, and spleen and liver metastasis in the intrasplenic nude mouse model injected with HT29 colon cancer cells.

      Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
      Catalogue Number533851
      Brand Family Calbiochem®
      Synonyms2-Acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione, 2-Acetylnaphtho[2,3-b]furan-4,9-dione, Spherogenesis Blocker, BBI-608
      DescriptionCancer Stemness Inhibitor, BBI608
      References
      ReferencesLi, Y., et al. 2015. Proc. Natl. Acad. Sci. USA 112, 1839.
      Product Information
      CAS number83280-65-3
      FormBrown solid
      Hill FormulaC₁₄H₈O₄
      Chemical formulaC₁₄H₈O₄
      Quality LevelMQ100
      Biological Information
      Primary TargetSTAT3
      Primary Target IC<sub>50</sub>142 nM
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      5.33851.0001 04055977286762