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SCC258 OVCAR-4 Human Ovarian Cancer Cell Line

OVCAR-4 high-grade serous ovarian carcinoma is a highly relevant model for multidrug-resistant ovarian cancer.

SCC258
≥1X10⁶ cells/vial   
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      Overview

      Replacement Information
      Description
      Catalogue NumberSCC258
      DescriptionOVCAR-4 Human Ovarian Cancer Cell Line
      Alternate Names
      • OVCAR4
      Background InformationOvarian carcinoma is a prevalent worldwide disease, with over 200,000 new cases diagnosed per year (1). The first-line chemotherapy for newly-diagnosed ovarian carcinoma is cisplatin, but despite high initial efficacy, the most common types of ovarian carcinomas frequently relapse into platinum-resistant forms and many demonstrate multi-drug resistance (1). The availability of cellular models that recapitulate both resistant and susceptible forms of the disease are essential to understanding drug resistance and advancing new options for treatment.

      OVCAR-4 is a high-grade serous ovarian adenocarcinoma cell line established from a patient refractory to cisplatin, and is resistant to multiple chemotherapeutic agents (2). OVCAR-4 cells are characterized by migration/invasion ability and are tumorigenic in nude mice (3). The OVCAR-4 cell line is homozygous for the Leu130Val mutation in TP53 (4) and expresses high levels of the cancer marker integrin αvβ3 (5). OVCAR-4 cells are recommended to be passaged at relatively high density (at least 13,000 cells/cm2). OVCAR-4 is one of the most representative cell lines for high-grade serous ovarian carcinoma and a highly relevant model for multidrug-resistant ovarian cancer.

      Source:
      OVCAR-4 was established from ascites from a 42-year-old patient with an ovarian tumor refractory to cisplatin treatment (2).

      References:
      1. Nat Rev Disease Primers 2016; 2: 16061.
      2. Cancer Res 1997; 57: 850—856.
      3. Gynecol Oncol 2015;138(2): 372-377.
      4. Mol Cancer Ther 2006; 5(11): 2606-2612.
      5. Bioorganic & Medicinal Chem 2018; 26: 2085-2091.
      References
      Product Information
      Applications
      ApplicationOVCAR-4 high-grade serous ovarian carcinoma is a highly relevant model for multidrug-resistant ovarian cancer.
      Key Applications
      • Cell Culture
      Application NotesThis product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com.
      Biological Information
      Cell Line Type
      • Cancer Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assurance• Each vial contains ≥ 1X10⁶ viable cells.
      • Cells are tested negative for infectious diseases by a Human Essential CLEAR panel by Charles River Animal Diagnostic Services.
      • Cells are verified to be of human origin and negative for inter-species contamination from rat, mouse, chinese hamster, Golden Syrian hamster, and non-human primate (NHP) as assessed by a Contamination CLEAR panel by Charles River Animal Diagnostic Services.
      • Cells are negative for mycoplasma contamination.
      • Each lot of cells is genotyped by STR analysis to verify the unique identity of the cell line.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
      Packaging Information
      Material Size≥1X10⁶ cells/vial
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      SCC258 04061842403486