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SCC203 IGROV-1 Human Ovarian Cancer Cell Line

IGROV-1 human ovarian carcinoma cell line is a versatile model for ovarian carcinoma and investigation of drug resistance.

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SCC203
≥1X10⁶ cells/vial   
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      Overview

      Replacement Information
      Description
      Catalogue NumberSCC203
      DescriptionIGROV-1 Human Ovarian Cancer Cell Line
      Alternate Names
      • Igrov-1
      • IGROV 1
      • IGR-OV1
      • IGROV1
      • OV1/P
      • OV1-P
      Background InformationThe IGROV-1 cell line is well-established as a model for drug-resistant ovarian carcinoma. IGROV-1 cells lack hormone receptors and exhibit low to moderate sensitivity to several common chemotherapeutic agents, while remaining sensitive to cisplatin (1). IGROV-1 cells harbor a paracentric inversion of chromosome 3 and a translocation between chromosomes 2 and 5 (1). The IGROV-1 cell line exhibits hypermutation and has an overall mutation profile similar to endometrioid carcinoma (2). IGROV-1 cells appear in culture as confluent monolayers and are highly tumorigenic in vivo, forming solid tumors within 15 days in nude mice (1). IGROV-1 cells are characterized by expression of vitronectin and αvβ3 integrin, essential for the observed migratory behavior of these cells toward ECM proteins (3), and express the cancer-associated target MDM2 (4).

      Source:
      IGROV-1 cells were established from a stage III ovarian solid primary tumor of a 47-year-old female patient (1).

      References:
      1. Cancer Res. 1985; 45(10): 4970-4979.
      2. Nat Commun. 2013; 4: 2126.
      3. Int J Cancer. 1999: 80(2): 285-294.
      4. Int J Cancer. 1996: 68(1): 67-74.
      References
      Product Information
      Applications
      ApplicationIGROV-1 human ovarian carcinoma cell line is a versatile model for ovarian carcinoma and investigation of drug resistance.
      Key Applications
      • Cell Culture
      Application NotesThis product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com.
      Biological Information
      Cell Line Type
      • Cancer Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assurance• Each vial contains ≥ 1X10⁶ viable cells.
      • Cells are tested negative for infectious diseases by a Human Essential CLEAR panel by Charles River Animal Diagnostic Services.
      • Cells are verified to be of human origin and negative for inter-species contamination from rat, mouse, chinese hamster, Golden Syrian hamster, and non-human primate (NHP) as assessed by a Contamination CLEAR panel by Charles River Animal Diagnostic Services.
      • Cells are negative for mycoplasma contamination.
      • Each lot of cells is genotyped by STR analysis to verify the unique identity of the cell line.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
      Packaging Information
      Material Size≥1X10⁶ cells/vial
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      SCC203 04061841689256