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328006 ERK Inhibitor - CAS 1049738-54-6 - Calbiochem

The ERK Inhibitor, also referenced under CAS 1049738-54-6, controls the biological activity of ERK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applicat

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Synonyms: 3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione, HCl

Primary Target: ERK
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328006
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Overview

Key Spec Table

CAS #Empirical Formula
1049738-54-6C₁₄H₁₆N₂O₃S • HCl

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328006-5MG
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      Description
      OverviewA cell-permeable and reversible thiazolidinedione compound that displays anti-proliferative properties (IC50 ≤ 25 µM in HeLa, A549, and SUM-159 tumor cells). Preferentially binds to ERK2 with a KD of ~5 µM and prevents its interaction with protein substrates. Shown to block ERK-mediated phosphorylation of ribosomal S6 kinase-1 (RSK-1) and ternary complex factor Elk-1 in HeLa cells, while exhibiting little effect on ERK1/2 phosphorylation by MEK1/2.
      Catalogue Number328006
      Brand Family Calbiochem®
      Synonyms3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione, HCl
      References
      ReferencesHancock, C. N., et al. 2005. J. Med. Chem. 48, 4586.
      Product Information
      CAS number1049738-54-6
      ATP CompetitiveN
      FormLight yellow solid
      Hill FormulaC₁₄H₁₆N₂O₃S • HCl
      Chemical formulaC₁₄H₁₆N₂O₃S • HCl
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetERK
      Primary Target IC<sub>50</sub>≤ 25 µM for anti-proliferative properties in HeLa, A549, and SUM-159 tumor cells; KD of ~5 µM for ERK2
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      328006-5MG 04055977196351