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370665 Guanosine-3ʹ-5ʹ-cyclic Monophosphate, 8-(4-Chlorophenylthio)-, Triethylammonium Salt - Calbiochem

Selective membrane-permeable activator of protein kinase G that has a higher activation potential than cGMP.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 8-pCPT-cGMP, TEA

Primary Target: Protein kinase G
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₁₆H₁₄ClN₅O₇PS · (CH₃CH₂)₃NH
      Description
      OverviewSelective membrane-permeable activator of protein kinase G that has a higher activation potential than cGMP. Does not significantly affect cGMP-regulated phosphodiesterases. Inhibits the thrombin-induced phosphorylation of human platelets mediated by myosin light chain kinase (MLCK) and protein kinase C (PKC). Note: 25 µmol = 14.73 mg.
      Catalogue Number370665
      Brand Family Calbiochem®
      Synonyms8-pCPT-cGMP, TEA
      References
      ReferencesAlioua, A., et al. 1998. J. Biol. Chem. 273, 32950.
      Draijer, R., et al. 1995. Circ. Res. 77, 895.
      Geiger, J., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 1031.
      Wolfe, L., et al. 1989. J. Biol. Chem. 264, 7734.
      Product Information
      ATP CompetitiveN
      FormLyophilized
      Hill FormulaC₁₆H₁₄ClN₅O₇PS · (CH₃CH₂)₃NH
      Chemical formulaC₁₆H₁₄ClN₅O₇PS · (CH₃CH₂)₃NH
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetProtein kinase G
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      370665 0

      Documentation

      Guanosine-3ʹ-5ʹ-cyclic Monophosphate, 8-(4-Chlorophenylthio)-, Triethylammonium Salt - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Guanosine-3ʹ-5ʹ-cyclic Monophosphate, 8-(4-Chlorophenylthio)-, Triethylammonium Salt - Calbiochem Certificates of Analysis

      TitleLot Number
      370665

      References

      Reference overview
      Alioua, A., et al. 1998. J. Biol. Chem. 273, 32950.
      Draijer, R., et al. 1995. Circ. Res. 77, 895.
      Geiger, J., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 1031.
      Wolfe, L., et al. 1989. J. Biol. Chem. 264, 7734.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-July-2008 RFH
      Synonyms8-pCPT-cGMP, TEA
      DescriptionSelective membrane-permeable activator of protein kinase G. Has a higher activation potential than cGMP. Does not significantly affect cGMP-regulated phosphodiesterases. Inhibits the thrombin-induced phosphorylation of human platelets mediated by myosin light chain kinase (MLCK) and protein kinase C (PKC). Note: 25 µmol = 14.73 mg
      FormLyophilized
      Chemical formulaC₁₆H₁₄ClN₅O₇PS · (CH₃CH₂)₃NH
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (1 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesAlioua, A., et al. 1998. J. Biol. Chem. 273, 32950.
      Draijer, R., et al. 1995. Circ. Res. 77, 895.
      Geiger, J., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 1031.
      Wolfe, L., et al. 1989. J. Biol. Chem. 264, 7734.