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07-1223 Anti-Protein Phosphatase 2 C α/β Antibody

Detect Protein Phosphatase 2 C α/β using this Anti-Protein Phosphatase 2 C α/β Antibody validated for use in WB.

Anti-Protein Phosphatase 2 C α/β Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Kinases & Phosphatases Gene Symbol: PPM2C, PDPC, PDP1, FLJ32517, PDH, PDP, MGC119646, EC 3.1.3.43 UniProt Number: Q9P0J1
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07-1223
100 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      B, H, M, RWBRbPurifiedPolyclonal Antibody
      Description
      Catalogue Number07-1223
      ReplacesAB4090
      DescriptionAnti-Protein Phosphatase 2 C α/β Antibody
      Alternate Names
      • Protein phosphatase 2C
      • Pyruvate dehydrogenase
      • Pyruvate dehydrogenase phosphatase, catalytic subunit 1
      • Lipoamide-phosphatase 1, mitochondrial precursor
      • Protein phosphatase 2C, magnesium-dependent, catalytic subunit
      • Pyruvate dehydrogenase (Lipoamide) phosphatase-phosphatase
      • Pyruvate dehydrogenase phosphatase
      Background InformationPP-2 C α/β is heterodimer located in the mitochondrial matrix. Within the pyruvate dehydrogenase complex, PP-2 C α/β serves to catalyze the dephosphorylation and concomitant reactivation of the E1 component’s alpha subunit. Mutations occurring in the PDP1 gene are the cause of a disease known as pyruvate dehydrogenase deficiency (PDP deficiency), which leads to neurological dysfunction from lactic acidosis.
      References
      Product Information
      FormatPurified
      Control
      • L6 Cell Lysate
      PresentationPurified immunoglobulin in phosphate buffered saline with 0.08% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect Protein Phosphatase 2 C α/β using this Anti-Protein Phosphatase 2 C α/β Antibody validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenPurified peptide conjugated to KLH.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes the alpha/beta regulatory subunit isotype of protein phosphatase 2C (PP2C). PP 2C alpha/beta polyclonal antibody binds a 44-46 kDa protein.
      Species Reactivity
      • Bovine
      • Human
      • Mouse
      • Rat
      Species Reactivity NoteProven to react with human and rat. Expected to react with mouse based on sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • PPM2C
      • PDPC
      • PDP1
      • FLJ32517
      • PDH
      • PDP
      • MGC119646
      • EC 3.1.3.43
      Purification MethodProtein Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9P0J1 # Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (By similarity).
      COFACTOR: Binds 2 magnesium ions per subunit (By similarity).
      SIZE: 537 amino acids; 61054 Da
      SUBUNIT: Heterodimer of a catalytic subunit and a FAD protein of unknown function (By similarity).
      SUBCELLULAR LOCATION: Mitochondrion matrix (By similarity).
      DISEASE:SwissProt: Q9P0J1 # Defects in PDP1 are the cause of pyruvate dehydrogenase phosphatase deficiency (PDP deficiency) [MIM:608782]. PDP deficiency results in lactic acidosis leading to neurological dysfunction.
      SIMILARITY: SwissProt: Q9P0J1 ## Belongs to the PP2C family.
      Molecular WeightApprox. 46 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in L6 cell lysates.
      Western Blot Analysis: 1:500 dilution of this lot detected PP-2 C ALPHA/BETA on 10 ug of L6 lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      07-1223 04053252409974