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672152 uPA Inhibitor II, UK122 - Calbiochem

The uPA Inhibitor II, UK122 controls the biological activity of uPA. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

uPA Inhibitor II, UK122 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-((5-Oxo-2-phenyl-4(5H)-oxazolylidene)methyl)benzenecarboximidamide, trifluoroacetate

672152
  
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₇H₁₃N₃O₂ • CF₃CO₂H
Description
OverviewA cell-permeable oxazolidinone-carboxamidine compound that acts as a potent, selective, and active-site targeting inhibitor of urokinase-type plasminogen activator (uPA; IC50 = 200 nM) with much reduced activity against trypsin, thrombin, tPA, and plasmin (38%, 8%, 5%, and 0% inhibition, respectively, with 100 µM UK122). Shown to effectively inhibit the migration and invasion (80% and 68% inhibition, respectively, with 100 µM UK122), but not proliferation, of uPA-expressing CFPAC-1 pancreatic cells.
Catalogue Number672152
Brand Family Calbiochem®
Synonyms4-((5-Oxo-2-phenyl-4(5H)-oxazolylidene)methyl)benzenecarboximidamide, trifluoroacetate
References
ReferencesZhu, M., et al. 2007. Mol. Cancer Ther. 6, 1348.
Product Information
FormYellow solid
Hill FormulaC₁₇H₁₃N₃O₂ • CF₃CO₂H
Chemical formulaC₁₇H₁₃N₃O₂ • CF₃CO₂H
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
672152 0

Documentation

uPA Inhibitor II, UK122 - Calbiochem Certificates of Analysis

TitleLot Number
672152

References

Reference overview
Zhu, M., et al. 2007. Mol. Cancer Ther. 6, 1348.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision06-Febuary-2009 RFH
Synonyms4-((5-Oxo-2-phenyl-4(5H)-oxazolylidene)methyl)benzenecarboximidamide, trifluoroacetate
DescriptionA cell-permeable oxazolidinone-carboxamidine compound that acts as a potent, selective, and active-site targeting inhibitor of urokinase-type plasminogen activator (uPA; IC50 = 200 nM) with much reduced activity against trypsin, thrombin, tPA, and plasmin (38%, 8%, 5%, and 0% inhibition, respectively, with 100 µM UK122). Shown to effectively inhibit the migration and invasion (80% and 68% inhibition, respectively, with 100 µM UK122), but not proliferation, of uPA-expressing CFPAC-1 pancreatic cells.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₇H₁₃N₃O₂ • CF₃CO₂H
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (25 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesZhu, M., et al. 2007. Mol. Cancer Ther. 6, 1348.