Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

532628 Vps34 Inhibitor, VPS34-IN1 - CAS 1383716-33-3 - Calbiochem

A cell-permeable, highly potent, selective, and reversible inhibitor of Vps34 activity (IC₅₀ = 25 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1-(2-(2-Chloropyridin-4-ylamino)-4ʹ-(cyclopropylmethyl)-4,5ʹ-bipyrimidin-2ʹ-ylamino)-2-methylpropan-2-ol, Vacuolar Protein Sorting 34 Inhibitor, PIK3C3 Inhibitor

Primary Target: Vps34
532628
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1383716-33-3C₂₁H₂₄ClN₇O

Products

Catalogue NumberPackaging Qty/Pack
5.32628.0001 Glass bottle 5 mg
Description
OverviewA cell-permeable pyridinylaminobipyrimidinylamino compound that acts as a highly potent, selective, and reversible inhibitor of Vps34 activity (IC50 = 25 nM using recombinant Vsp34:Vps15 complex). Displays excellent selectivity over 340 other protein kinases and 25 lipid kinases (even at ~ 1 µM), including class I and class II PI 3-kinases. Does not affect Ser473 or Thr308 phosphorylation status of Akt. Suppresses endosomal localization of GFP-2xFYVEHrs (IC50 = 100 nM) in U2OS cells. Rapidly inhibits SGK3 activity in a dose-dependent manner (~40% inhibition at 100 nM) and causes a diminution in T-loop and hydrophobic motif phosphorylation.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number532628
Brand Family Calbiochem®
Synonyms1-(2-(2-Chloropyridin-4-ylamino)-4ʹ-(cyclopropylmethyl)-4,5ʹ-bipyrimidin-2ʹ-ylamino)-2-methylpropan-2-ol, Vacuolar Protein Sorting 34 Inhibitor, PIK3C3 Inhibitor
References
ReferencesBago, R., et al. 2014. Biochem. J. 463, 413.
Product Information
CAS number1383716-33-3
FormWhite powder
Hill FormulaC₂₁H₂₄ClN₇O
Chemical formulaC₂₁H₂₄ClN₇O
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetVps34
Primary Target IC<sub>50</sub>25 nM using recombinant Vsp34:Vps15 complex
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5.32628.0001 04055977281835

Documentation

Vps34 Inhibitor, VPS34-IN1 - CAS 1383716-33-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Bago, R., et al. 2014. Biochem. J. 463, 413.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-April-2015 JSW
Synonyms1-(2-(2-Chloropyridin-4-ylamino)-4ʹ-(cyclopropylmethyl)-4,5ʹ-bipyrimidin-2ʹ-ylamino)-2-methylpropan-2-ol, Vacuolar Protein Sorting 34 Inhibitor, PIK3C3 Inhibitor
DescriptionA cell-permeable pyridinylaminobipyrimidinylamino compound that acts as a highly potent, selective, and reversible inhibitor of Vps34 activity (IC50 = 25 nM using recombinant Vsp34:Vps15 complex). Displays excellent selectivity over 340 other protein kinases and 25 lipid kinases (even at ~ 1 µM), including class I and class II PI 3-kinases. Does not affect Ser473 or Thr308 phosphorylation status of Akt. Suppresses endosomal localization of GFP-2xFYVEHrs (IC50 = 100 nM) in U2OS cells. Rapidly inhibits SGK3 activity in a dose-dependent manner (~40% inhibition at 100 nM) and causes a diminution in T-loop and hydrophobic motif phosphorylation.
FormWhite powder
Intert gas (Yes/No) Packaged under inert gas
CAS number1383716-33-3
Chemical formulaC₂₁H₂₄ClN₇O
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml). Use only fresh DMSO for reconstitution.
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBago, R., et al. 2014. Biochem. J. 463, 413.