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677175 Vinblastine Sulfate - CAS 143-67-9 - Calbiochem

Antitumor alkaloid drug.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: Interaction of tubulin with microtubule-associated proteins, specifically Tau and MAP2
677175
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
143-67-9C₄₆H₅₈N₄O₉ · H₂SO₄

Products

Catalogue NumberPackaging Qty/Pack
677175-10MG Plastic ampoule 10 mg
Description
OverviewAntitumor alkaloid drug. Induces apoptosis in cultured hepatocytes and human lymphoma cells. Affects interaction of tubulin with microtubule-associated proteins, specifically Tau and MAP2. Depolymerizes microtubules. Increases frequency of micronucleated erythrocytes.
Catalogue Number677175
Brand Family Calbiochem®
References
ReferencesTanaka, E., et al. 1995. J. Cell. Biol. 128, 139.
Boscoboinik, D., et al. 1994. Biochem. Biophys. Res. Commun. 199, 374.
Smith, C.D., et al. 1994. Cancer Lett. 79, 213.
Smith, C.D., et al. 1994. Cancer Res. 54, 3779.
Tsukidate, K., et al. 1993. Am. J. Pathol. 143, 198.
Jagetia, G.C., and Jacob, P.S. 1992. Mutat. Res. 280, 87.
Jordan, M.A., et al. 1992. J. Cell Sci. 102, 401.
Prasad, V., et al. 1992. J. Protein Chem. 11, 509.
Product Information
CAS number143-67-9
ATP CompetitiveN
FormWhite crystalline solid
Hill FormulaC₄₆H₅₈N₄O₉ · H₂SO₄
Chemical formulaC₄₆H₅₈N₄O₉ · H₂SO₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetInteraction of tubulin with microtubule-associated proteins, specifically Tau and MAP2
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSYY8400000
Safety Information
R PhraseR: 22-37/38-61-41

Harmful if swallowed.
Irritating to respiratory system and skin.
May cause harm to the unborn child.
Risk of serious damage to eyes.
S PhraseS: 22-26-36/37/39-45

Do not breathe dust.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful & Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
677175-10MG 04055977260595

Documentation

Vinblastine Sulfate - CAS 143-67-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Vinblastine Sulfate - CAS 143-67-9 - Calbiochem Certificates of Analysis

TitleLot Number
677175

References

Reference overview
Tanaka, E., et al. 1995. J. Cell. Biol. 128, 139.
Boscoboinik, D., et al. 1994. Biochem. Biophys. Res. Commun. 199, 374.
Smith, C.D., et al. 1994. Cancer Lett. 79, 213.
Smith, C.D., et al. 1994. Cancer Res. 54, 3779.
Tsukidate, K., et al. 1993. Am. J. Pathol. 143, 198.
Jagetia, G.C., and Jacob, P.S. 1992. Mutat. Res. 280, 87.
Jordan, M.A., et al. 1992. J. Cell Sci. 102, 401.
Prasad, V., et al. 1992. J. Protein Chem. 11, 509.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision31-July-2014 JSW
DescriptionAntitumor alkaloid drug. Induces apoptosis in cultured hepatocytes and human lymphoma cells. Affects interaction of tubulin with microtubule-associated proteins, specifically Tau and MAP2. Depolymerizes microtubules. Increases the frequency of micronucleated erythrocytes.
FormWhite crystalline solid
CAS number143-67-9
RTECSYY8400000
Chemical formulaC₄₆H₅₈N₄O₉ · H₂SO₄
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityH₂O (50 mg/ml)
Storage Protect from moisture
Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful & Carcinogenic / Teratogenic
Merck USA index14, 9982
ReferencesTanaka, E., et al. 1995. J. Cell. Biol. 128, 139.
Boscoboinik, D., et al. 1994. Biochem. Biophys. Res. Commun. 199, 374.
Smith, C.D., et al. 1994. Cancer Lett. 79, 213.
Smith, C.D., et al. 1994. Cancer Res. 54, 3779.
Tsukidate, K., et al. 1993. Am. J. Pathol. 143, 198.
Jagetia, G.C., and Jacob, P.S. 1992. Mutat. Res. 280, 87.
Jordan, M.A., et al. 1992. J. Cell Sci. 102, 401.
Prasad, V., et al. 1992. J. Protein Chem. 11, 509.