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505017 UBP310 - CAS 902464-46-4 - Calbiochem

UBP310 - CAS 902464-46-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: GluK1/GluK3 antagonist, UBP310, (S)-1-(2-Amino-2-carboxyethyl)-3-(2­-carboxy-thiophene-3-yl-methyl)-5-methylpyrimidine­-2,4-dione, UBP-310, UBP 310

Primary Target: GluK1
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
902464-46-4C₁₄H₁₅N₃O₆S
Description
OverviewA potent antagonist highly selective for GluK1 (Kb = 10 nM), GluK3 (IC50 = 23 nM), and GluK1/K5 (Kb = 8 nM) subtype kainate receptors. Does not interact with GluK2 and GluK2/K5 receptors. Low affinity to AMPA receptors (Kd = 83 µM). Does not interact with mGluR1 or NMDA receptors at concentration less than 10 µM. Often used in studying neuronal excitability and synaptic plasticity.
Catalogue Number505017
Brand Family Calbiochem®
SynonymsGluK1/GluK3 antagonist, UBP310, (S)-1-(2-Amino-2-carboxyethyl)-3-(2­-carboxy-thiophene-3-yl-methyl)-5-methylpyrimidine­-2,4-dione, UBP-310, UBP 310
References
ReferencesPinheiro, S., et al. 2013. Cereb. Cort. 23, 323.
Atlason, T., et al. 2010. Mol. Pharmacol. 78, 1036.
Perrais, D., et al. 2009. Neuropharmacol. 56, 131.
Dolman, P., et al. 2007. J. Med. Chem. 50, 1558.
Mayer, L., et al. 2006. J. Neurosci. 26, 2852.
Product Information
CAS number902464-46-4
FormWhite solid
Hill FormulaC₁₄H₁₅N₃O₆S
Chemical formulaC₁₄H₁₅N₃O₆S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetGluK1
Primary Target K<sub>i</sub>10nM
Secondary targetGluk3
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
505017 0

Documentation

UBP310 - CAS 902464-46-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Pinheiro, S., et al. 2013. Cereb. Cort. 23, 323.
Atlason, T., et al. 2010. Mol. Pharmacol. 78, 1036.
Perrais, D., et al. 2009. Neuropharmacol. 56, 131.
Dolman, P., et al. 2007. J. Med. Chem. 50, 1558.
Mayer, L., et al. 2006. J. Neurosci. 26, 2852.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-July-2013 JSW
SynonymsGluK1/GluK3 antagonist, UBP310, (S)-1-(2-Amino-2-carboxyethyl)-3-(2­-carboxy-thiophene-3-yl-methyl)-5-methylpyrimidine­-2,4-dione, UBP-310, UBP 310
DescriptionA potent antagonist highly selective for GluK1 (Kb = 10 nM), GluK3 (IC50 = 23 nM), and GluK1/K5 (Kb = 8 nM) subtype kainate receptors. Does not interact with GluK2 and GluK2/K5 receptors. Low affinity to AMPA receptors (Kd = 83 µM). Does not interact with mGluR1 or NMDA receptors at concentration less than 10 µM. Often used in studying neuronal excitability and synaptic plasticity.
FormWhite solid
CAS number902464-46-4
Chemical formulaC₁₄H₁₅N₃O₆S
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (100 mM)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesPinheiro, S., et al. 2013. Cereb. Cort. 23, 323.
Atlason, T., et al. 2010. Mol. Pharmacol. 78, 1036.
Perrais, D., et al. 2009. Neuropharmacol. 56, 131.
Dolman, P., et al. 2007. J. Med. Chem. 50, 1558.
Mayer, L., et al. 2006. J. Neurosci. 26, 2852.