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612085 Tie2 Kinase Inhibitor - CAS 948557-43-5 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-(6-Methoxy-2-naphthyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole

612085
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
948557-43-5C₂₆H₂₁N₃O₂S
Description
Overview

This product has been discontinued.



A cell-permeable pyridinylimidazole compound that acts as a potent, reversible, and ATP-binding site-targeting inhibitor of Tie2 (IC50 = 250 nM) with ~ 200-fold selectivity over p38 MAPK and greater than 10-fold selectivity over VEGFR2, VEGFR3, and PDGFR1β. Shown to exhibit antiangiogenesis activity in a Matrigel assay (70% reduction, 50 mg/kg/0.5 day, i.p.) and inhibit the growth of xenografted tumor (no apparent growth up to 20 days, 25 mg/kg/0.5 day, i.p.) in mice in vivo.
Catalogue Number612085
Brand Family Calbiochem®
Synonyms4-(6-Methoxy-2-naphthyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole
References
ReferencesSemones, M., et al. 2007. Bioorg. Med. Chem. Lett. 17, 4756.
Product Information
CAS number948557-43-5
FormOrange-tan solid
Hill FormulaC₂₆H₂₁N₃O₂S
Chemical formulaC₂₆H₂₁N₃O₂S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
S PhraseS: 22-24/25

Do not breathe dust.
Avoid contact with skin and eyes.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
612085 0

Documentation

Tie2 Kinase Inhibitor - CAS 948557-43-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Tie2 Kinase Inhibitor - CAS 948557-43-5 - Calbiochem Certificates of Analysis

TitleLot Number
612085

References

Reference overview
Semones, M., et al. 2007. Bioorg. Med. Chem. Lett. 17, 4756.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision25-May-2011 RFH
Synonyms4-(6-Methoxy-2-naphthyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole
DescriptionA cell-permeable pyridinylimidazole compound that acts as a potent, reversible, and ATP-binding site-targeting inhibitor of Tie2 (IC50 = 250 nM) with ~200-fold selectivity over p38 MAPK and greater than 10-fold selectivity over VEGFR2, VEGFR3, and PDGFR1β. Shown to exhibit antiangiogenesis activity in a Matrigel assay (70% reduction, 50 mg/kg/0.5 day, i.p.) and inhibit the growth of xenografted tumor (no apparent growth up to 20 days, 25 mg/kg/0.5 day, i.p.) in mice in vivo.
FormOrange-tan solid
Intert gas (Yes/No) Packaged under inert gas
CAS number948557-43-5
Chemical formulaC₂₆H₂₁N₃O₂S
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesSemones, M., et al. 2007. Bioorg. Med. Chem. Lett. 17, 4756.