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580551 Tautomycin, Streptomyces spiroverticillatus - CAS 109946-35-2 - Calbiochem

Tautomycin, CAS 109946-35-2, is a potent inhibitor of protein phosphatase 1, 2A, and smooth muscle endogenous phosphatase (IC₅₀ = 1 nM, 10 nM, and 6 nM, respectively). Mixture of two isomers.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: PP1
580551
  
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Overview

Key Spec Table

CAS #Empirical Formula
109946-35-2C₄₁H₆₆O₁₃
Description
OverviewMixture of two isomers. Potent inhibitor of protein phosphatases. Inhibits protein phosphatase 1 (IC50 = 1 nM), protein phosphatase 2A (IC50 = 10 nM), and smooth muscle endogenous phosphatase (IC50 = 6 nM). Higher concentrations are needed to inhibit protein phosphatase 2B. Does not inhibit protein phosphatase 2C.
Catalogue Number580551
Brand Family Calbiochem®
References
ReferencesMcCluskey, A., et al. 2002. J. Med. Chem. 45, 1151.
Mitsuhashi, S., et al. 2001. Biochem. Biophys. Res. Commun. 287, 328.
Kikuchi, K., et al. 1999. Int. J. Mol. Med. 4, 395.
Sheppeck, J.E., et al. 1997. J. Org. Chem. 62, 387.
Sugiyama, Y., et al. 1996. Bioorg. Med. Chem. Lett. 6, 3.
Gong, M.C., et al. 1992. J. Biol. Chem. 267, 14662.
Suganuma, M., et al. 1992. Toxicon 30, 873.
MacKintosh, C. and Klumpp, S. 1990. FEBS Lett. 277, 137.
Magae, J., et al. 1989. J. Antibiot. 42, 1290.
Product Information
CAS number109946-35-2
ATP CompetitiveN
FormLyophilized thin film
Hill FormulaC₄₁H₆₆O₁₃
Chemical formulaC₄₁H₆₆O₁₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetPP1
Primary Target IC<sub>50</sub>1 nM, 10 nM, 6 nM, against protein phosphatase 1, protein phosphatase 2A, and smooth muscle endogenous phosphatase, respectively
Purity≥97% by HPLC
Physicochemical Information
Cell permeableN
Safety Information according to GHS
RTECSWX1000000
Safety Information
R PhraseR: 26/27/28

Very toxic by inhalation, in contact with skin and if swallowed.
S PhraseS: 22-36/37/39-45

Do not breathe dust.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Highly Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage -20°C
Protect from Light Protect from light
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.



From Catalog:
Desc. Field- removed ". . .and useful for studies involving protein phosphorylation"
- removed ". . .or phorbol dibutyrate binding. Does not activate protein kinase C or inhibit myosin light chain kinase
Global Trade Item Number
Catalogue Number GTIN
580551 0